大鼠下丘脑交叉上核的肽能传出投射  

PEPTIDERGIC EFFERENT PROJECTIONS OF THE RAT HYPOTHALAMICSUPRACHIASMATIC NUCLEUS

作　　者：张彭三[1] 张凤真[1] 王梅申[1] 

机构地区：[1]徐州医学院解剖学教研室,徐州221002

出　　处：《解剖学杂志》1995年第6期521-525,共5页Chinese Journal of Anatomy

基　　金：国家自然科学基金资助项目

摘　　要：用HRP逆行追踪术观察了大鼠下丘脑交叉上核的传出投射,并进一步通过HRP逆行追踪结合免疫组化的方法观察了交叉上核投射神经元的性质.结果表明:交叉上核有稀疏的投射分布到下丘脑前核前部、腹内侧核、背内侧核、室周核、背侧区、丘脑室旁核和带旁核.交叉上核投射的主要靶区是下丘脑室旁核下区和室旁核,交叉上核的加压素能和血管活性肠肽能神经元参与这一投射.另外,HRP逆行追踪表明除本实验所涉及的神经肽外,还有其他神经递质参与这一投射.文内还就交叉上核向下丘脑室旁核下区和室旁核的投射及其化学性质进行了讨论.The eferent, projections of the suprachiasmatic nucleus (Sch) in rat were examined by usingthe retrograde tracer HRP. SCh projection neurons were further investigated with a combinedretrograde tracer-immunohistochemical method. The results showed that SCh had sparse efferent fibers that projected to AHA, VMH, DMD, Pe, DA, PV and PT. The major terminal fieldsof SCh-derived VP and VIP were detected in the subparaventricular zone and Pa. In addition,HRP tracing indicated the existence of SCh projections which could not ascribed to one of thepresently investigated peptides. The possible functional role of the subparaventricular zone and Painnervated by SCh as well as their neurotransmitters was discussed.

关 键 词：下丘脑 交叉上核 投射神经元 神经肽 大鼠 

分 类 号：Q954.52[生物学—动物学] R322.81[医药卫生—人体解剖和组织胚胎学]