急性甲胺磷中毒患儿血清肌钙蛋白T和心肌酶水平的研究  

Changes of Serum Cardiac Troponin T and Myocardial Enzyme Concentrations and Clinical Symptom in Children with Acute Methmidophos Poisoning

作　　者：雷后兴[1] 周杰林[1] 雷文芬[2] 吴静[2] 樊慧苏[2] 樊必夫[1] 

机构地区：[1]丽水市人民医院儿科,浙江323000 [2]温州医学院附属第六医院儿科

出　　处：《中国预防医学杂志》2005年第4期303-305,共3页Chinese Preventive Medicine

摘　　要：目的探讨急性甲胺磷中毒患儿血清肌钙蛋白T和心肌酶水平的变化及临床意义。方法对39例急性甲胺磷中毒患儿(中毒组)分别于住院第1天、第3天和第7天测定血清肌钙蛋白T(cTnT)和心肌酶水平,并与30例正常儿童(对照组)进行比较分析。结果中毒组入院第1天、第3天和第7天cTnT均明显高于正常对照组,均值间差异有统计学意义(P<0.001);血清肌酸激酶(CK)、肌酸激酶心型同功酶(CK-MB)、乳酸脱氢酶(LDH)、天冬氨酸转移酶(AST)和α-羟丁酸脱氢酶(α-HBDH)住院第1天、第3天明显高于对照组,均值间的差异均有统计学意义(P均<0.001);住院第7天,CK和AST降至正常水平,但CK-MB、LDH和α-HBDH仍高于对照组,均值间差异均有统计学意义(P分别为<0.01和<0.05)。结论急性甲胺磷中毒患儿均有不同程度的心肌损害;cTnT和心肌酶水平测定对判断急性甲胺磷中毒是否有心肌损害有重要价值。Objective To explore the changes of serum cardiac troponin T （cTnT） and myocardial enzyme concentrations and their clinical significance. Methods 39 cases with acute methmidophos poisoning （poisoned group） were tested of the level of serum cTnT and myocardial enzyme on the first, the tlfird and the seventh day of admission.The results were contrasted with 30 healthy chil- dren （control group） and analyzed. Results The level of serum cTnT in the poisoned group were higher titan those in the control group （P 〈 0.001 ） .On the first and the third day of admission, the levels of sertun creatine kinase （CK）, creatine kinase isoenzyme （CK- MB）, lactate dehydrogenase （LDH）, aspartate aminotansfemse （AST） and α- hydrooxybutryrate dehydrogenase （α- HBDH ） in the poisoned group were higher than those in the contrast group （P 〈 0.001）. On the seventh day of admission, CK and AST reduced to the normal level. But CK- MB, LDH and α- HBDH remained Ifigher than those in the control group （ P 〈 0.01 and P 〈 0.05） . Conclusions Children with acute methmidophos poisoning will have myocardial injury as a whole. Exanination of cardiac troponin T and myocardial enzyme concentrations has great value in diagnosing children of acute methnidophos poisoning complicated with myocar- dial injury.

关 键 词：急性甲胺磷中毒 血清 肌钙蛋白T 心肌酶 小儿 心肌损害 

分 类 号：R725.9[医药卫生—儿科]