氟啶酸眼用缓释凝胶的制备及释药研究  

Study on flumark,sustained-release ophthalmic gel and on the release

作　　者：张卫[1] 钟华玉[1] 唐瑞嫦 钟银送 杨彩群[1] 

机构地区：[1]江门市第二人民医院药剂科,广东江门529000

出　　处：《广东药学》2005年第4期28-30,共3页Guangdong Pharmaceutical Journal

摘　　要：目的制备氟啶酸眼用缓释凝胶并研究其释放机理。方法建立UV测定制剂的含量及体外释药量,建立HPLC测定制剂离体角膜渗透量,采用溶出度法进行处方的体外释药试验,应用离体角膜进行体外渗透试验。结果亲水凝胶材料含量越小,氟啶酸从凝胶基质中释放越快,体外释药符合一级释放动力学方程;亲水凝胶含量高,体外释放符合H iguch i方程。结论氟啶酸眼用凝胶达到了缓慢释放的目的。Objective TO prepare flumark ,sustained-release ophthalmic gel and investigate its mechanism of release. Method The release test of formulation was conducted with permeable membrane,The content and the release amount of flumark from gel base were determined by UV. The cornea permeation test of formulation was studied with rabbit corneas. The Permeant amount of flumark was determined by high performance liquid chromatography. Result The formulation release behavior in vitro followed the first-order kinetic equation with the less amount of polymer （2.0% -3.0% ） in the formulation ;or followed Higuchi equation with the higher amount of polyer （4.0%） in the formulation. The permeability of flumark was raised significantly With the less amount of polyer in the formulation. The formulation Permeation behavior in vitro followed the zero-order kinetic equation. Conclusion The release time of flumark ophthalmic gel-forming solution was longer.

关 键 词：氟啶酸 凝胶剂 释药 离体角膜渗透 

分 类 号：R944.1[医药卫生—药剂学]