Effects of Acupuncture at Shenshu （BL 23） on Morphine Withdrawal Syndrome and c-fos Expression in Addiction-relative Brain Regions （Abstract）  

作　　者：刘胜 周文华 刘惠芬 赵伟康 杨国栋 

出　　处：《Journal of Acupuncture and Tuina Science》2005年第4期16-16,共1页针灸推拿医学（英文版）

摘　　要：Objective： To probe the effect of electroacupuncture （EA） at Shenshu （BL 23） on morphine withdrawal syndrome and the mechanism. Methods： Morphine dependence was induced in the rat by subcutaneous injection of morphine, and the acute withdrawal syndrome was precipitated by intraperitoneal administration of naloxone. The rats were pretreated with 100 Hz EA at Shenshu （BL 23） for one hour before the naloxone challenge. Withdrawal scores were calculated, and c-fos levels were detected by immunocytoche mical method. Results： EA at Shenshu （BL 23） could obviously inhibit withdrawal syndrome, decreased expression of c-los in the PAG, paraventricular hypothalamus nucleus, lateral hypothalamic area and hypocampus while EA increase c-fos positive neurons in the a mygdula and core of nucleus accumbens. Conclusion： EA at Shenshu （BL 23） can effectively inhibit morphine withdrawal syndrome and many central nucleus groups are involved in the inhibition of EA on opioid medicine dependence.

关 键 词：针灸疗法 中医治疗 吗啡依赖 基因表达 麻醉剂中毒 脑疾病 

分 类 号：R259.955[医药卫生—中西医结合] R246.6[医药卫生—中医内科学]