2型糖尿病患者血浆中可溶性血栓调节蛋白的意义  

Significance of plasma soluable thrombomodulin in type 2 diabetic patients

作　　者：唐小龙[1] 蔡淑玉[1] 张荣波[1] 周昕[1] 

机构地区：[1]安徽理工大学医学院检验教研室,淮南233003

出　　处：《中华内分泌代谢杂志》2005年第4期316-317,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：检测了50例2型糖尿病患者和50例对照者血浆中凝血和纤溶相关因子。结果患者血浆中纤溶相关因子增高;在糖尿病患者中,可溶性血栓调节蛋白(sTM)与蛋白C(PC)呈负相关,而与纤溶酶α2抗纤溶酶复合物呈正相关。表明患者sTM升高与凝血和纤溶系统活化相关。Proteins in coagulative and fibrinolytic systems were measured in 50 type 2 diabetic patients and 50 normal controls. Proteins related with fibrinolytic system in the diabetic patients were significantly higher than those in normal controls. The concentration of soluble thrombomodulin （sTM） was negatively correlated with the activity of protein C and positively correlated with plasmin-α2-antiplasmin complex in type 2 diabetic patients, suggesting that the increase of sTM is associated with hypercoagulability and enhanced fibrinolysis.

关 键 词：2型糖尿病 血浆 可溶性血栓调节蛋白 蛋白质C 抗纤维蛋白溶酶 

分 类 号：R587.1[医药卫生—内分泌]