慢性荨麻疹患者血清特异性IgE和T淋巴细胞检测  

The Analysis of Specific IgE and T Lymphocyte in Chronic Urticaria

作　　者：赵宏丽[1] 孙晓慧[1] 李孟娟[1] 赵俊芳[1] 

机构地区：[1]天津市长征医院检测中心,300021

出　　处：《天津医药》2005年第9期558-559,共2页Tianjin Medical Journal

基　　金：天津市卫生局科技基金资助项目(项目编号:99KYZD06)

摘　　要：目的:分析慢性荨麻疹的致病因素以及细胞免疫功能的改变。方法:采用免疫印迹法体外半定量检测血清特异性IgE,采用流式细胞仪双色直接免疫荧光法分析T淋巴细胞亚群。结果:305例慢性荨麻疹患者中109例患者至少对一种过敏原呈阳性反应,阳性率为35.74%,57例健康献血员的特异性IgE检测全部为阴性,两组比较差别有统计学意义(χ2=22.95,P<0.05)。在18种常见变应原的检测中发现,户尘螨的阳性率最高,达13.77%,而且中重度过敏者(Ⅲ级以上)达4.92%。结论:慢性荨麻疹的病因复杂,部分患者是由于接触变应原引起的I型变态反应,同时伴有T淋巴细胞免疫功能紊乱。Objective： The Analysis of nosogenesis and immunocytic function in Chronic Urticaria. Methods：Immunoblot was used to test the serum sIgE. T Lymphocyte subspecies was tested by immediate immune fluorescence. Results：35.74%（109/ 305） of patients were positive with specific IgE. Whereas 57 blood donators were negative entirely. There are statistially significant （P 〈 0.05） differences in the two groups. Positive ratio of Dermatophagoides pteronyssinus in 18 specises of allergen was the highest, 13.77% and median or serious patients obtained 4.92%. Conclusion： The nosogenesis of Chronic Urticaria is complex. A part of patients are cased by type Ⅰ allergy, accompanied by function disorder of T Lymphocyte.

关 键 词：慢性荨麻疹 血清 特异性IGE T淋巴细胞 Ⅰ型变态反应 免疫功能 

分 类 号：R758.24[医药卫生—皮肤病学与性病学] R446.11[医药卫生—临床医学]