精液中前列腺特异抗原与纤维连接蛋白相关性的研究  

Relativity of the concentration of prostate special antigen and fibronectin in semen

作　　者：高杨[1] 孟凡伟[2] 刘玉强[2] 刘延红[1] 夏洪印[1] 

机构地区：[1]山东大学齐鲁医院中心实验室,山东济南250012 [2]山东大学齐鲁医院泌尿外科,山东济南250012

出　　处：《山东大学学报（医学版）》2005年第8期709-711,共3页Journal of Shandong University:Health Sciences

基　　金：山东省计划生育委员会科研基金资助课题(9819)。

摘　　要：目的:检测精液中前列腺特异抗原(prostatespecialantigen,PSA)与纤维连接蛋白(fi-bronectin,FN)含量,分析其相关性,以探讨其对精液液化的影响。方法:将精液标本按不同的液化时间分为:60min内不液化组(A组)47例和60min内液化组(B组)30例,采用时间分辨荧光分析法检测精液PSA,酶联免疫法检测FN含量,对所得结果行独立样本t检验和相关性分析。结果:PSA含量比较:A组为(0.849±0.563)mg/ml;B组为(1.779±0.22)mg/ml;两组比较,差异有统计学意义(P<0.01)。FN含量比较:A组为(148.74±2.51)ng/ml,B组为(115.39±1.83)ng/ml,A组含量显著高于B组,两组比较差异有统计学意义(P<0.01)。精液中PSA与FN含量呈负相关(r=-0.04,p<0.05)。结论:精液中PSA含量下降,FN水解减少,造成精液液化异常。Objective： To discuss the effect of prostate special antigen（PSA） and fibronectin（FN） in liquefying semen. Methods： According to the time of liquescence, patients were divided into two groups： semen liquefying dysfunction within 60 minutes （group A, n= 47）, semen liquefying within 60 minutes （group B, n=30）. The quantity of PSA by the sperm plasma was examined by time-resolved fluoroimmunoassay, the concentration of FN was detected by ELISA. Finally the data were analyzed with SPSS11.5 for windows. Results： The PSA concentration was （0.849±0.563） mg/ml in group A, （1.779±0.22）mg/ml in group B;there were significant difference between group A and B （P〈0.01）. The FN concentration was （148.7443±2.51） ng/ml in group A, （115.39±1.83）ng/ml in group B;there were significant difference between group A and B （P〈0.01）. There was a negative correlation between the concentrations of SPA and FN. Conclusion： The reducing PSA and the increasing fibronectin may delay the time of the seminal liquefaction.

关 键 词：精液 液化异常 前列腺特异抗原 纤连蛋白类 

分 类 号：R698.2[医药卫生—泌尿科学] R446.6[医药卫生—外科学]