二甲双胍治疗多囊卵巢综合征的临床疗效观察  

Clinical effect of metformin in treating polycystic ovary syndrome

作　　者：朱小莉[1] 孙宝治[2] 李晓林[2] 

机构地区：[1]山东大学威海分校校医院,山东威海264209 [2]青岛市立医院妇产科,山东青岛266011

出　　处：《山东大学学报（医学版）》2005年第8期766-768,共3页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨二甲双胍治疗多囊卵巢综合征(polycysticovarysyndrome,PCOS)的作用及机制。方法:选择30例PCOS患者作为研究对象,口服二甲双胍,1500mg/d,连续12周。观察服用二甲双胍后患者的临床特征、性腺激素及糖代谢指标的变化。结果:PCOS患者经二甲双胍治疗后,BMI、WHR、LH、LH/FSH比值、T、A、DHEAS、FI、HomaIR、Homaβcell均较治疗前明显降低(P<0.01,P<0.05),ISI较治疗前明显增高(P<0.05)。结论:二甲双胍可显著改善PCOS患者的临床特征,其机制与二甲双胍降低胰岛素水平、提高胰岛素的敏感性密切相关。Objective ： To explore the effect and mechanism of metformin on patients with polycystic ovary syndrome （PCOS）. Methods： Thirty patients with PCOS were selected to take metformin of 1500mg daily for 12 weeks, and they were observed the changes of their clinical features, reproductive hormones and glucose metabolisms. Results： BMI, WHR, LH, LH/FSH ratio, T, A, DHEAS, FI, Homa IR and Homa β cell were decreased significantly （P〈0.01 ,P〈0.05）, but ISI was increased significantly （P〈0.05）,Conclusion： Metformin may effectively improve the clinical features of PCOS, which may be related to its improvement on insulin resistance .

关 键 词：多囊卵巢综合征 胰岛素抵抗 二甲双胍 

分 类 号：R711.75[医药卫生—妇产科学]