双肾双夹易卒中型肾血管性高血压大鼠重要靶器官小窝蛋白的表达  

The Expression of caveolin-1 in Brain, Heart, Kidney and Blood Vessel in the Stroke-prone Renovascular Hypertensive Rats

作　　者：李兰芳[1] 李峰[1] 朱炳阳[1] 廖端芳[1] 陈临溪[1] 

机构地区：[1]湖南衡阳南华大学药理学教研室,湖南衡阳421001

出　　处：《高血压杂志》2005年第8期492-495,共4页Chinese Journal of Hypertension

基　　金：国家自然科学基金(NO.30371645);湖南省教育厅优秀青年基金(03B036)资助

摘　　要：目的研究在高血压发展过程中重要靶器官组织信号蛋白小窝蛋白(Caveolin-1)的表达。方法建立双肾双夹易卒中型肾血管性高血压大鼠动物模型,随机分为高血压组和假手术组,用Westernblot的方法检测小窝蛋白在心、脑、肾血管中的表达。结果2周末高血压组血压明显升高,4周末高血压组心脏体重比明显升高,高血压组重要靶器官心、脑、肾、血管中小窝蛋白的表达随高血压的时程发展明显减少。结论双肾双夹易卒中型肾血管性高血压大鼠重要靶器官组织小窝蛋白表达减少,提示小窝蛋白信号途径可能参与高血压的发生发展,与高血压靶器官的损害有关。Objective To inveqtigate the expression of caveolin-1 in brain, heart, kidney and blood vessel in the experimental renovascular hypertension in RHRsp rats. Methods Renovascular model of hypertension（RHRsp） was established by partly narrowing of two bilateral renal arteries in SD rats. The rats were divided into two groups at random. （ 1 ） control sham operation group（ n=40 ） ; （ 2 ） hyperten- sion group（n=40）. The expression of caveolin-1 were determined by Western blot. Results The expression of caveolin-1 was decreased significantly in brain, heart, kidney and blood vessel tissue in RHRsp rats. Conclusion Alteration of caveolin-1 may be associated in the process of hypertension and the damage of target organs.

关 键 词：大鼠 高血压 小窝蛋白 易卒中型肾血管性高血压大鼠 信号蛋白 靶器官 双肾 Western 高血压组 大鼠动物模型 

分 类 号：R544.1[医药卫生—心血管疾病]