组织工程心脏瓣膜细胞生物学研究进展  

Progress in cytobiology of tissue-engineered heart valve

作　　者：叶晓峰 [1] 董念国 [1] 孙宗全 [1] 冷希岗 [2] 

机构地区：[1]430022,武汉,华中科技大学同济医学院附属协和医院心外科 [2]300192,天津,中国医学科学院,中国协和医科大学生物医学工程研究所

出　　处：《国外医学（生物医学工程分册）》2005年第4期222-226,共5页Foreign Medical Sciences(Biomedical Engineering Fascicle)

基　　金：国家自然科学基金资助项目(30371414)

摘　　要：由于现有的机械瓣和生物瓣仍存在种种不足,如不具备生长性、需抗凝、易感染、不能生长和自我修复等。组织工程心脏瓣膜是一新兴的研究领域,涉及多门学科。构建组织工程心脏瓣膜应包括支架的制作、细胞的种植、瓣膜的体外培养和最终移植入人体。其中种植的细胞是组织工程心脏瓣膜的基本要素。就组织工程心脏瓣膜的细胞生物学研究进展做一综述。Tissue engineering of heart valves is an evolving research field. Driven by the need to overcome the shortcomings of heart valve substitutes currently available, such as need for anticoagulation, susceptibility to infections, inability to grow and autorepair, the multidisciplinary approach for designing and growing viable heart valves identical to the natives heart valves has been attracting increasing attention. Cytobiology should be one of the essential aspects in constructing tissue-engineered heart valve. This article will give an update of recent developments, current limitations and potential future applications of cytobiology in constructing tissue-engineered heart valves.

关 键 词：组织工程 心脏瓣膜 细胞 

分 类 号：R318.01[医药卫生—生物医学工程]