妊娠期妇女血清甘胆酸与血脂水平相关性研究  

Study on the Relationship Between the Levels of Serum Cholyglycine (CG) and Blood Lipids in Pregnant Women

作　　者：尤建飞[1] 吕时铭[1] 王琼[1] 朱宇宁[1] 

机构地区：[1]浙江大学医学院附属妇产科医院检验科,310006

出　　处：《放射免疫学杂志》2005年第4期286-288,共3页Journal of Radioimmanology

摘　　要：目的:探讨妊娠期妇女肝内胆汁淤积症(ICP)的发病率及甘胆酸(CG)与血脂、碱性磷酸酶(ALP)水平的相关性。方法:采用放射免疫分析检测甘胆酸,用酶法测定血脂,速率法测定ALP。结果:2040例妊娠期妇女中有18.5%CG值升高,其中有2.8%可确诊为ICP。ICP患者与正常妊娠组相比,TG、CHOL、LDL、ALP均明显升高,而HDL则略降低。结论:ICP为妊娠期常见并发症,应将CG作为常规产前检查项目。ICP患者结合分析其血脂、ALP水平,有助于病情判断。Objective To investigate the prevalence of intrahepatic cholestasis during pregnancy and the relationship between levels of serum CG and blood lipids. Methods Serum CG, blood lipid and liver function profile were examined in 2040 women with pregnancy during the second or third trimester, Among these pregnant women, 57 were diagnosed as with intrahepatic cholestasis. Blood lipids （ TG, cholesterol, HDL, LDL） and ALP levels in 50 of the 57 pregnant women were studied and compared with those in 50 otherwiee normal pregnant women as controls, Results Serum CG levels were above normal range in 372 of the 2040 pregnant women （ 18.5% ）, Fifty seven of these 372 pregnant women were confirmed to be with intrahepatie eholestasis （2.8% of the 2040 pregnancies）, The TG, cholesterol, LDL contents and ALP levels in the pregrant women with intrahepatie eholestasis were significantly higher cull （P 〈 0.05） but HDL contents were slightly lower （P 〉 0, 05） than those in controls, Conclusion Intrahepatie eholestasis developed in a substantial proportion of pregnant women （2, 8% in this study） and should be carefully monitored due to possible damage to the fetus, Serum CG was shown to be an early and sensitive marker for the diagnosis of intrahepatie eholestasis. Changes of blood lipid and ALP levels were related to disease status.

关 键 词：妊娠期 女性 血清 甘胆酸 血脂 实验室检查 放射免疫分析 

分 类 号：R714[医药卫生—妇产科学] R446.11[医药卫生—临床医学]