EMS患者红细胞免疫功能与脂质过氧化的关系  

Study on the Relationship Between Red Blood Cell Immunity and Lipid Peroxidation in Patients with Endometriosis

作　　者：杨静秀[1] 施绍红[1] 王玉平[1] 解雪芹[1] 秦继宝[1] 

机构地区：[1]江苏省连云港市东方医院,222042

出　　处：《放射免疫学杂志》2005年第4期311-312,共2页Journal of Radioimmanology

摘　　要：目的:探讨了子宫内膜异位症(EMS)患者红细胞免疫功能的变化及其与脂质过氧化的关系。方法:应用红细胞酵母花环法测定54例EMS患者红细胞免疫功能和化学比色法测定血浆丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)含量,并与30名正常健康人作比较。结果:EMS患者红细胞免疫复合物(RBC-IC)花环率和MDA水平明显升高(P<0.05～0.01),而红细胞C3b受体(RBCC3b-RR)、SOD、GSH-PX、SOD/MDA低于正常(P<0.01)。相关分析显示,RBCC3b花环与MDA呈显著负相关(r=-0.4428,P<0.05)、RBC-ICR与MDA呈正相关(r=0.5488,P<0.05)。结论:EMS患者红细胞免疫功能降低,与活性氧代谢紊乱密切相关。Objective To assess the relationship between red blood cell immunity and lipid pemxidation （LPO） in patients with endometriosis. Methods The percentage of positive red blood cell c3b receptor rosette （ RBCC3b - RR） and red blood cell immune complex rosette （RBC - ICR ） were examined in 54 patients with endometriosis and 30 controls. Serum levels of malondialdehyde （MDA） , superoxidase （SOD） and glutathione peroxidase （GSH -PX） were measured by chemocolorimetry in these subjects. Re-sulks Percentage of positive RBC - ICR and MDA levels were significantly higher in patients with endometriosis than those in controls （ P 〈 0.05 - 0.01 ） , while RBC -C3b RR, SOD, GSH - PX, SOD/MDA ratio were significantly lower in patients with endometriosis than those in controls （P 〈0.01 ）. The percentage of positive RBCC3b -RR was negatively correlated with MDA levels （r = -0. 4428,P 〈 0.05 ） and RBC - ICRR was positively correlated with MDA（ r = 0. 5488,P0.05 ）. Conclusion The lower red cell immune adhension function was closely associated with the disturbance of metabolism of lipid peroxidation in patietns with endometriosis.

关 键 词：红细胞 免疫功能 脂质过氧化 子宫内膜异位症 丙二醛 实验室检查 

分 类 号：R711.71[医药卫生—妇产科学]