双黄升白颗粒剂对小鼠白细胞减少症的影响  

Effect of Shuanghuang Shengbai granule on radiotherapy or chemotherapy induced leukopenia in mice

作　　者：沈云辉[1] 陈长勋[1] 徐振晔[2] 

机构地区：[1]上海中医药大学药理教研室,上海201203 [2]上海中医药大学附属龙华医院,上海200032

出　　处：《中国中药杂志》2005年第16期1275-1279,共5页China Journal of Chinese Materia Medica

基　　金：上海市科学技术委员会资助项目(02DZ19136)

摘　　要：目的:观察双黄升白颗粒剂对环磷酰胺(CTX)及Se-137放射源照射所致小鼠白细胞减少症的影响。方法:CTX腹腔注射或Se-137放射源照射造成小鼠白细胞(WBC)减少症模型,用双黄升白颗粒剂进行治疗,对模型小鼠外周血象,胸腺脾脏指数,骨髓有核细胞数(BMNC),脾结节数(CFU-s)进行检测,并进行骨髓细胞分类计数和骨髓病理观察。结果:双黄升白颗粒剂可明显升高模型小鼠的WBC,BMNC,CFU-S,使骨髓细胞粒红比值恢复正常,并有保护骨髓造血微环境作用。结论:双黄升白颗粒剂具有明显升高白细胞作用。Objective： To observe the effect of Shuanghuang Shengbai granule on mice leukopenia induced by ip cyclophosphamide （CTX） or radiation. Method： Mice leukopenia models were induced by ip CTX or radiation, and then treated with Shuanghuang Shengbai granule per oral. The peripheral hemogram, thymus index, spleen index, bone marrow nucleated cell （BMNC） and colony forming unit-spleen （CFU-S） were detected. The bone marrow cell differentiation was examined. The pathological slices of bone marrow were observed. Result： Shuanghuang Shengbai granule could increase the WBC, BMNC, CFU-S of model mice significantly; Shuanghuang Shengbai granule could make the granulocyte and erythrocyte index recovered to normal level and it could also protect the bone marrow hemotopoietic microenvironment from the harm of radiation, Conclusion： Shuanghuang Shengbai granule has apparent leukogenic function.

关 键 词：双黄升白颗粒剂 白细胞减少症 升高白细胞作用 

分 类 号：R285.5[医药卫生—中药学]