鹅不食草挥发油对角叉菜胶致大鼠急性胸膜炎的影响  

Effects of the volatile oil of Centipeda minima on acute pleural effusion in rats induced by an intrapleural injection of Car

作　　者：覃仁安[1] 梅璇[1] 宛蕾[2] 师晶丽[3] 沈映君[4] 

机构地区：[1]贵阳医学院附属医院,贵州贵阳550004 [2]贵阳医学院,贵州贵阳550004 [3]中山大学第五附属医院,广东珠海519000 [4]成都中医药大学,四川成都610075

出　　处：《中国中药杂志》2005年第15期1192-1194,共3页China Journal of Chinese Materia Medica

基　　金：贵州省科委科学基金项目(20002)

摘　　要：目的:研究鹅不食草挥发油的抗炎作用及其可能的机制。方法:采用角叉菜胶致大鼠急性胸膜炎模型,观察鹅不食草挥发油大剂量(0.05mL·kg-1)、小剂量(0.1mL·kg-1)对急性炎症的影响。结果:鹅不食草挥发油对大鼠胸膜炎模型白细胞数增高表现出明显的对抗作用,能明显减少大鼠胸膜炎渗出液中一氧化氮(NO)的产生和前列腺素E2(PGE2)的生成,大剂量组能明显对抗胸膜炎大鼠血清中C反应蛋白(CRP)和肿瘤坏死因子(TNFα)的升高。结论:鹅不食草挥发油对角叉菜胶致大鼠急性胸膜炎有明显的保护作用。Objective： To study the anti-inflammation effect of volatile oil of Centipeda minima and the mechanism of action. Method： The animal model was induced by the Car injection into intrapleural of rats, to observe the effect of VOCM on acute inflammation. Result： VOCM was able to inhibit the increase of NO, CRP and proinflammatory cytokines such as TNFα in the acute inflammation of the rat body. Conclusion： VOCM has a protective effect on acute pleural effusion in rats induced by an intrapleural injection of Car.

关 键 词：鹅不食草挥发油 抗炎 角叉菜胶 C反应蛋白 细胞因子 

分 类 号：R285.5[医药卫生—中药学]