胃灵颗粒治疗消化性溃疡的临床与实验研究  

Clinical and Experimental Study on Weiling Granule for Treatment of Peptic Ulcer

作　　者：林禾禧[1] 王奕珊[1] 朱国曙[1] 张闽光[1] 林振川[1] 陈奕昭[1] 何成龙[1] 吕方[1] 杨春波[2] 谢振家 

机构地区：[1]福建省泉州市中医院,泉州市温陵南路215号362000 [2]福建中医学院附属第二医院 [3]福建省新药药理研究基地

出　　处：《中医杂志》2005年第8期590-592,共3页Journal of Traditional Chinese Medicine

基　　金：福建省卫生厅资助项目(503)

摘　　要：目的:研究胃灵颗粒对消化性溃疡愈合质量(QOUH)和大鼠乙酸慢性胃溃疡愈合质量的影响。方法:用随机分组的方法,观察临床消化性溃疡的复发率并用苏木精伊红染色对大鼠愈合性胃溃疡再生黏膜进行定量观察,测定胃壁结合黏液量、胃酸、胃蛋白酶活性。结果:胃灵颗粒组能降低消化性溃疡的复发率,改善胃溃疡大鼠胃黏膜的组织损伤并提高胃壁结合黏液量,减少胃酸的排出。结论:胃灵颗粒能提高 QOUH,是临床抗消化性溃疡复发的可能机制之一。To study on effects of Weiling Granule on union of peptic ulcer and the gastrical ulcer induced by acetic acid in the rat. Methods：With random grouping method,the clinical recurrence rate of peptic ulcer,and regenerated macosa of healing gastric ulcer in the rat was investigated quantitatively with hematoxylin-eosin staining,and gastric wall combining macus amount ,gastric acid and pepsin activity were determined. Results：Welling Granule could decrease the recurrence rate of peptic ulcer,improve injury of the tissue of gastric macosa in the rat,increase gastric wall combining mucus amount,and decrease secretion of gastric acid. Conclusion： Weiling Granule can increase quality of ulcerative healing, which is possibly one of the mechanisms of antirecurrence of peptic ulcer clinically.

关 键 词：胃灵颗粒 消化性溃疡 胃黏膜 中药制剂 复发 

分 类 号：R259[医药卫生—中西医结合]