造血干细胞移植后移植物抗宿主病中医辨证初探  

Preliminary Study on TCM Syndrome Differentiation of Graft Versus Host Disease after Transplantation of the Hemopoietic Stem Cell

作　　者：李海燕[1,2] 冯四洲[1,2] 韩明哲[1,2] 

机构地区：[1]中国医学科学院 [2]中国协和医科大学血液学研究所,天津市南京路288号300020

出　　处：《中医杂志》2005年第8期617-618,共2页Journal of Traditional Chinese Medicine

摘　　要：目的:探索造血干细胞移植后移植物抗宿主病(GVHD)的中医辨证特点,以期为进一步研究本病治疗提供临床辨治依据。方法:对62例 GVHD 患者按急慢性分组共计85例次进行中医辨证观察。结果:急性移植物抗宿主病(aGVHD)50例次,湿热型占68%,半数有肝损害黄疸,血热阴虚型占32%,病情偏重者较多;慢性移植物抗宿主病(cGVHD)35例次,湿热型占25.7%,且多兼阴虚、血瘀,阴虚型占74.3%。结论:GVHD 常见基本中医证型为湿热和阴虚型。aGVHD 以湿热型多见,重症患者在血热阴虚型中易见;cGVHD 则以阴虚型为主;随着病情加重和病程延长阴虚证型呈增多趋势。To explore characteristics of TCM syndrome differentiation of graft versus host disease（GVHD） after transplantation of the hemopoietic stem cell.so as to provide basis of clinical syndrome differentiation for further studying on treatment of this disease. Methods： 62 cases of GVHD were grouped according to acute or chronic GVHD. and a total of 85 cases-times were investigated for TCM syndrome differentiation. Results：in 50 cases-times of acute GVHI）,damp-heat type accounted for 68% and 50% have jaundice due to hepatic injury;blood-heat and Yin-deficiency accounted for 32% ,with more patients of more severe condition. In 35 cases-times of chronic GVHD,damp-heat type accounted for 25. 7% with more patients companied with Yin-deficiency,blood stasis and Yin-deficiency rate accounted for 71.3%. Conclusion ：Commonly-seen basic TCM syndrome types of GVHD are damp-heat and Yin-deficiency types. Damp-heat type was more common in acute GVHD and blood-heat and Yin-deficiency type was more frequently found in severe patients;chronic GVHD manifest mainly as Yin-deficiency type and with exacerbation of condition and prolongation of disease course, Yin-deficiency type tends to increase.

关 键 词：造血干细胞移植 移植物抗宿主病 中医辨证 免疫抑制类药 临床表现 

分 类 号：R259[医药卫生—中西医结合]