静脉注射二氢埃托啡致急性中毒的诊断与解救  

The Diagnosis and Treatment of 28 Cases of Acute Intoxication Caused by Dihydroetorphine Intravenous Injection

作　　者：赵国厚[1] 赵怀壁[1] 张在恒[1] 金伟秋[1] 吴鹏兰[1] 李青[1] 

机构地区：[1]昆明医学院第二附属医院急诊科

出　　处：《昆明医学院学报》1995年第1期26-28,共3页Journal of Kunming Medical College

摘　　要：对急诊收治的２８例静脉注射二氢埃托啡（ＤＨＥ）致急性中毒病人的诊断及治疗进行总结讨论．结果提示ＤＨＥ若应用不当可造成呼吸严重抑制、低氧血症、酸中毒、休克、脉管栓塞及多脏器功能损害；一次剂量过大可致呼吸骤然停止；解救不及时病人可死于呼吸或多脏器功能衰竭．临床上依据①青少年突发昏迷；②用过“口含片”，有呼吸抑制、瞳孔缩小及缺氧症；③较多静脉针痕及脉管栓塞硬化；④纳洛酮有特效拮抗等特征进行诊断．临床救治以迅速解除呼吸抑制、氧疗及保护生命器官功能为主．8 cases of acute intoxication caused by dihydroetorphine(DHE)intravenous injectionwere analysed.The result shows that if it is misused,DHE can cause serious respiratory de-pression,hypoxemia,acidosis,shock,vessel embolism and polyorgan damage.It can causeabrupt respiratory cease when excessively used.The patients may die of respiratory failure orpolyorgan disfunction if there is no timely rescue.Here is the following of diagnostic basis ofacute intoxication by DHE intravenous injection:①sudden unconsciousness of juvenile;②having used the ″sublingual tablets″and having the syndrome of respiratory depression,pupiles narrow and anoxia; ③ much cicatrice of injection in vein,vessel embolism andsclerosis;④naloxone is the specific antagonist against DHE.The clinical treatment includesthe relief of respiratory depression rapidly,oxygenotherapy and the pretection of importantorgan′sfunction.

关 键 词：二氢埃托啡 药物中毒 诊断 解救 

分 类 号：R595.405[医药卫生—内科学]