灯盏花总黄酮抗大鼠心肌缺血及对正常大鼠血流动力学的影响  

Protective Effects of Total Flavonoids Isolated from Erigerom breviscapus on Myocardial Ischemia and Hemodynamic Effects in Anesthetized Rats

作　　者：李玲[1] 陈必义[1] 吴婉玲[1] 李新华[1] 陈植和[1] 

机构地区：[1]昆明医学院天然药物药理重点实验室

出　　处：《昆明医学院学报》1995年第3期45-49,共5页Journal of Kunming Medical College

摘　　要：观察灯盏花总黄酮对抗异丙肾上腺素所致大鼠心肌缺血，以及两种给药途径（静脉、十二指肠）对麻醉大鼠血流动力学的影响．结果表明：灯盏花总黄酮能减轻异丙肾上腺素诱发的大鼠心肌缺血性损伤；ｉｖ灯盏花总黄酮１００ｍｇ．ｋｇ－１能明显降低血压，同时不增快心率，对其它血流动力学参数影响不明显；十二指肠一次性给药（１９２ｍｇ．ｋｇ－１）有相似于静脉给药的变化趋势，但达不到统计学意义．he total flavonoids were isolated from Eriheron briviscapus.The protective effects of theflavonoids on isoproterenol-induced ischemic myocardial injury in rats and hemodynamic effects ofthe flavonoids iv or intraduodenally in anesthetized rats were studied.The results showed thatthe flavonoids abated isoproterenol-induced ischemic myocardial injury in rats.Following intra-venous administration of the flavonoids l00mg.kg-1 to normal anesthetized rats ,the blood pres- sure was markedly lowered at 2～60 min,without increasing heart rate.But no obvious influ- ences to the rest of hemodynamic parameters were observed,The tendency of hemodynamics changes after intraduodenally administration of the flavonoids 192 mg.kg-1 was similar to intra- venous administration without any significance in statistics.

关 键 词：灯盏花 总黄酮 异丙肾上腺素 心肌缺血 血流动力 

分 类 号：R259.414[医药卫生—中西医结合]