乙型肝炎患者白细胞介素－1活性及其抑制因子观察  

Observation of Interleukin-1 Activity and its Inhibitor Factor in Patients with Hepatitis B

作　　者：文启明 王心禾[1] 

机构地区：[1]武汉冶金医学高等专科学校附院,同济医科大学附属协和医院

出　　处：《临床肝胆病杂志》1995年第4期185-187,共3页Journal of Clinical Hepatology

摘　　要：用胸腺细胞增殖法检测８７例各种临床类型乙肝患者白细胞介素－１（ＩＬ－１）活性，结果显示各型乙肝病人ＩＬ－１活性均显著低于正常对照组。增加检测标本稀释度或在ＩＬ－１诱生阶段加入消炎痛反见ＩＬ－１活性升高。提示乙肝患者ＩＬ－１活性下降并非其产生减少，而是与前列腺素类抑制物增多有关。Abstract The IL-1 activities of peripheral blood monocytes of 87 cases of Various clinical types with viral hepatitis B were measured with mouse thymocytes proliferation assay. The results showed that IL-1 activities of the patients were obviously lower than that of the normal controls. This process can be blocked by indomethacin or rising dilution degree. It suggested that the decreased IL-1 activities of the patients were not due to decrease of IL-1 production, but were caused by the increase of PGE-like inhibitor.

关 键 词：乙型肝炎 病理 白细胞介素1 抑制因子 前列腺素 

分 类 号：R512.620.2[医药卫生—内科学]