新抗凝治疗SLE小鼠的实验研究  

Study of acenocoumarolum on BXSB mice with SLE

作　　者：姜学义[1] 韩春雷[1] 峰下哲[2] 王黎曼 

机构地区：[1]北京医科大学第三医院皮肤科,100083 [2]东京医科齿科大学难治疾患研究所

出　　处：《临床皮肤科杂志》1995年第5期287-290,共4页Journal of Clinical Dermatology

基　　金：国家自然科学基金

摘　　要：观察了新抗凝片对SLE动物模型BXSB小鼠的治疗作用。结果显示：小鼠发病后其纤溶功能低下，主要是血中t－PA活性明显低于正常（P＜0．01），尿蛋白明显增加（P＜0．05）；用新抗凝片（1mg／kg／d）灌胃20天后，t－PA活性恢复正常，尿蛋白量和免疫复合物在肾小球的沉积明显低于未治疗组（P＜0．05，P＜0．01）。实验证明新抗凝片具有恢复病鼠纤溶功能的作用，从而阻止或清除肾小球免疫复合物和纤维蛋白的沉积，使病损得以修复，对SLE具有治疗作用。In the present study,the effect of acenocoumarolum on BXSB mice with SLE and its mechanism arc reported. After the onset of disease, the fibrinolytic function became low, the activity of tissuetype plasminogen activator(t-PA) in plasma was significantly lower than that in normal group. After administration of acenocoumarolum (1 mg/kg/d) for 20 days, the amount of proteinuria decreased (P<0. 05) and the immunopathologic and histologic changes of BXSB mice with lupus nephritis significantly improved (P<0.01 ). Meanwhile the activity of t-PA returned to normal. The result showed that acenocoumarolum could arever the fibrinolytic function on mice with SLE, prevent or remove the deposition of fibrin and immune complex on the glomerulus and improve the renal lesion. It could be used as a useful therapeutic agent in SLE.

关 键 词：系统性红斑狼疮 红斑狼疮 纤维蛋白 抗凝治疗 

分 类 号：R593.241[医药卫生—内科学]