充血性心力衰竭时血浆β-啡肽含量的变化与意义  

The changes of plasma beta-endorphin level in patients with congestive heart failure and their significance

作　　者：陈志坚[1] 张银环[1] 

机构地区：[1]同济医科大学心血管病学研究所,武汉430022

出　　处：《临床心血管病杂志》1995年第1期21-23,共3页Journal of Clinical Cardiology

摘　　要：测定了20例正常人及34例充血性心力衰竭(CHF)患者血浆β-内啡肽(β-EP)含量及部分患者的心脏泵功能参数(CO、CI).结果表明:CHF患者β-EP含量显著高于正常人;β-EP含量与心力衰竭严重程度呈正相关,与心力衰竭病因无关,而与CO、CI呈负相关.提示:CHF患者血浆β-EP含量显著升高,β-EP含量可以反映心力衰竭的严重程度.The plasma beta-endorphin(β-EP) levels in 20 normal persons and in 34 patients with congestive heart failure (CHF) were determined, and the cardiac function was assessed in some of the patients. The results showed:①The plasma β-EP levels were significantly higher in patient with CHF than in normal persons ;②Plasmaβ-EP levels were positively correlated with severity of heart failure and corresponded with cardiac function before and after treatment ; ③Plasma β-EP levels were not related to the causes of CHF,but negatively correlated with cardiac output and cardiac index. The results indicate that plasma β-EP levels are elevated in patients with CHF,plasma β-EP levels can reflex the severity of heart failure and β-EP may participate in the pathophysi-ologic process of CHF.

关 键 词：充血性 心力衰竭 Β内啡肽 心功能 病理化学 

分 类 号：R541.610.2[医药卫生—心血管疾病]