氨力农和多巴酚丁胺治疗重度充血性心力衰竭疗效比较  

A comparison of clinical effects of amrinone and dobutamine in severe congestive heart failure

作　　者：林国生[1] 胡昭明[1] 高淑英[1] 赵华月[1] 

机构地区：[1]同济医科大学附属同济医院心内科,武汉430030

出　　处：《临床心血管病杂志》1995年第3期144-147,共4页Journal of Clinical Cardiology

摘　　要：分别用国产氨为农(Am)和多巴酚丁胺(Dob)静脉输注治疗30例重度充血性心力衰竭(CHF)患者,对二药的疗效和不良反应进行了比较.结果显示,用药后3天内,二药的疗效无显著差异;用药后4～6天,Am的疗效继续上升,而Dob的疗效则迅速逆转.可能与慢性CHF患者心肌细胞β受体密度下调和机能低下有关.此外,Am还能改善左室舒张功能,降低心肌耗氧量,减少心律失常的发生,因此,对于重度CHF患者,Am优于Dob.A study was done in 50 patients with severe congestive heart failure to appraise objectively whether the effect of amrinone (Am) or that of dobutamine(Dob) was better. Within 3 昫ays of treatment,both Am and Dob significantly improved the patients condition and left ventricular systolic function,but there were no statistical differences between Am-group and Dob-group. From the 4th to 6th day in Am-group,the drug effective rate kept rising to 86. 7%,but in Dob-group, the drug-effects reversed rapidly and the cardiosystolic function declined near to that before treatment ( P >0. 05),which might be relevent to the down-regulated density and depressed function of β-receptor. Furthermore,Am improved the left ventricular diastolic function( P <0. 01) .reduced the myocardial oxygen consumption and incidence of arrhythmia,while Dob had no action on left ventricular diastolic function,increased the myocardial oxygen consumption slightly and raised the incidence of ventricular arrhythmia. In conclusion, we believe that Am has an advantage over Dob in treating patients with severe congestive heart failure.

关 键 词：氨力农 多巴酚丁胺 充血性 心力衰竭 药物疗法 

分 类 号：R541.610.5[医药卫生—心血管疾病]