改变硒、维生素E饮食摄入量对红细胞变形性的影响  

The Effect of Intake of Selenium and Vitamin E in Food on Red Cell Deformability

作　　者：刘为民[1] 李广生[1] 张秀云[1] 王凡[1] 孙淑艳[1] 

机构地区：[1]长春白求恩医科大学应用基础医学研究所,白求恩医大一院检验科

出　　处：《临床血液学杂志》1995年第3期104-105,共2页Journal of Clinical Hematology

基　　金：国家"八五"攻关项目

摘　　要：饲予大鼠不同硒（Ｓｅ）、维生素Ｅ（ＶＥ）含量的饲料１０周。低Ｓｅ低ＶＥ组红细胞变形性、全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）、血清谷胱甘肽转硫酶（ＧＳＴ）、红细胞中铜锌超氧化物歧化酶（Ｃｕ、Ｚｎ－ＳＯＤ）活力降低，而血清脂质过氧化物（ＬＰＯ）含量增高。结果提示，饮食中适量的Ｓｅ和ＶＥ能够增强红细胞的变形能力，其机制可能是：①Ｓｅ维持Ｓｐｅｃｔｒｉｎ与红细胞膜骨架结合；②Ｓｅ和ＶＥ的抗氧化作用，减弱了ＬＰＯ对细胞膜的损伤。Wistar rats were maintained on the experimental diets of different dose Selenium(Se) or/and vitamin E(VE) for 10 weeks.The red cell deformability,glutathion peroxidase,glutathion-S-transferases and Cu,Zn-superoxide activity in rats which fed with Se and VE deficience diets were significently reducted,but lipid peroxides contents were increased.There were resemblances in the effects of Se or/and VE supplemented.but also were some differences.The results suggested that intake of Se and VE in food may influnce red cell deformability.

关 键 词：红细胞变形性 硒 维生素E 饮食摄入量 

分 类 号：R977.25[医药卫生—药品]