慢性支气管炎病人免疫状态的研究  

Studies on Immune Status in Adult Patients with Chronic Bronchitis

作　　者：杨永清[1] 陈汉平[1] 赵粹英[1] 王瑞珍[1] 洪海国[1] 

机构地区：[1]上海市针灸经络研究所

出　　处：《免疫学杂志》1995年第4期242-245,248,共5页Immunological Journal

基　　金：国家自然科学基金

摘　　要：本文对１６例慢性支气管炎病人的粘膜分泌性ＩｇＡ（ＳＩｇＡ）免疫、细胞免疫和体液免疫状态与２１例正常人进行了对照研究。结果显示：慢性支气管炎病人的唾液ＳＩｇＡ与总ＩｇＡ含量（ｐ＜０．０５，Ｐ＜０．０５）、外周血淋巴细胞ＰＷＭ刺激培养上清液中ＩｇＡ与ＩｇＭ含量（Ｐ＜０．００５，Ｐ＜０．００１）、血清ＩｇＧ与ＩｇＭ含量（Ｐ＜０．００１，Ｐ＜０．００５）以及外周血ＣＤ８￣＋与ＣＤ８￣＋Ｔ淋巴细胞数目（Ｐ＜０．０５，Ｐ＜０．０５）均较正常人明显降低，而患者鼻分泌液中ＳＩｓＡ、ＩｇＡ与总ＩｇＡ含量（Ｐ＜０．００１，Ｐ＜０．００５，Ｐ＜０．００１）、外周血ＩＬ－２Ｒ￣＋（活化）Ｔ细胞数目（Ｐ＜０．０５）均较正常人显著增加。表明慢性支气管炎病人从粘膜免疫到外周血细胞免疫与体液免疫状态的低下，但不排除由于慢性感染或潜在的炎症引起的某些免疫指征的反应性增强。Status of mucosal secretory IgA immunity,cellular immunity and humoral immunity in six-teen patients with chronic bronchitis were studied compared with normal controls,the concentrations of SIgAand total IgA in saliva(P<0.05,P<0.05), IgG and IgM in sera(P<0. 001,P<0.005),and the numbers ofCD3￣+ and CD8￣+ T lymphocytes in peripheral blood(P<0.05,P<0. 05),which from the patients,weresignificantly decreased, but levels of SIgA, IgA and total IgA in nasal secretions(P<0. 001,P<0. 005,P<0.001), and of IL- 2R￣+ T lymphocytes in peripheral blood(P<0. 05) from the patients were significantly in-creased.The results suggested that in chronic bronchitis patients mucosal,cellular and humoral immune re- sponses are reduced,which do not exclude increasing response to chronic infection or potential inflammationfor certain immune indices.

关 键 词：支气管炎 粘膜免疫 细胞免疫 体液免疫 免疫学 

分 类 号：R562.210.3[医药卫生—呼吸系统]