山茛菪硷及川芎嗪对肺水肿大鼠的生存率、肺指数及形态学观察  

Effects of anisodamine and tetramethylpyrurine on survival rate, pulmonary index and paghological changes of pulmonary edema in rat

作　　者：戴顺龄[1] 薛全福[1] 王树山 张静[3] 李长城[1] 吴云清[1] 

机构地区：[1]中国医学科学院基础医学研究所病理生理研究室 [2]北京儿科研究所附属儿童医院传染科 [3]张家口医学院病理生理教研室

出　　处：《中国病理生理杂志》1989年第2期89-93,共5页Chinese Journal of Pathophysiology

摘　　要：静脉注射肾上腺素可造成大鼠剧烈的致死性肺水肿,动物于5分钟内全部死亡,类似于临床上中枢性肺水肿,属混合性肺水肿。用中药山茛菪硷及川芎嗪进行预防,效果十分明显。以正常组、肺水肿组、山茛菪组、川芎嗪组为序,存活率为100%、0%、96%、80%。生存时间为30分、4分5秒±27秒、28分43秒±4分36秒、25分12秒±9分36秒。((?)+SD,生存时间计算,正常组30分钟处死,预防组30分钟不死者亦处死,均算30分钟。)肺指数为0.48±0.06、1.70±0.47、0.74±0.39、0.83±0.55。上述指标各组与肺水肿组相比,均P<0.01。病理镜检见肺水肿组肺组织的正常结构破坏,间质及肺泡充满大片水肿液,充血、出血,间质增宽、两预防组均接近正常组。结果表明两种药对大鼠肺水肿有明显预防作用。Pulmonary edema was induced by Adrenallne (Ad) administration (0.1mg/kg) in 20 rats. This type of edema is similar to neurogenic pulmonary edema. Acute progressive respiratory distress, eynosis and dyspnea occurred. All died within 5 min after Ad injection and the pulmonary index (PI)was 1.70±0.47((?)±SD). The PI of normal control group was 0.48±0.06 in 20 rats. Only temporary respiratory distress was found in the anisodamine prevented group. One of 23 died in 20 min after Ad injection. The mortality decreased to 4% and PI was 0.74±0.39 in 23 rats. In the tetramethylpyrarine prevented group, the animals only had temporary dyspnea and returned to normal quickly. The mortality decreased to 20%. PI was 0.83±0.55 in 20 rats. Results showed that PI of edema group was much higher than that of other three groups. All P<0.01. The morphological changes were also observed under light microscope, It was found that in pulmonary edema rats, the protein-rich fluid filled in alveolar and Interstitial spaces and ecchymosis blooding occured, but in prevented rats almost all the damages diminished.

关 键 词：山莨菪硷 川芎嗪 肺水肿 鼠 预防 

分 类 号：R969.4[医药卫生—药理学]