雷公藤服用者精液中乳酸脱氢酶及其同功酶C_4活性的研究  

ACTIVITIES OF LDH AND LDHC_4 IN SEMEN FROM USERS OF TRIPTERYGIUM WILFORDII

作　　者：亢继文[1] 贾太和[1] 董志英[1] 张春然[1] 

机构地区：[1]白求恩国际和平医院临床实验科,050082

出　　处：《男性学杂志》1995年第3期137-140,共4页

摘　　要：本文对19例中药雷公藤服用者精子、精浆中乳酸脱氢酶(LDH)及同功酶C_4(LDHC_4)的活性进行了测定分析。发现服药后以单位数量精子表示的LDHC_4活性在精子、精浆中均有明显升高(双侧非参数秩和检验,分别为P<0.01和P<0.02);通过酶活性与精子计数的相关分析,显示服药后精浆LDHC_4活性(mU/ml)与精子计数的正相关性(r=0.2279)较服药前(r=0.5505)弱,可能与精液中精子以外的其他LDHC_4来源贡献增大有关,诸如生精细胞的分解增多等。本文认为服药后精子LDHC_4活性上升,精液中非成熟精子比例增高是其原因之一。Total LDH and LDHC4 activities of sperm and seminal plasma from 19 users of Triptery-giurn Wilfordii Hook. f. (TW) were detected with the enzyme kinetics method. The results showed that the activity of LDHC4(mU/10sp) in both sperm and seminal plasma increased markedly after the administration of TW. The correlation coefficent of LDHC4(mU/ml) in seminal plasma obtained after medication (r = 0. 2279) was smaller than before (r = 0. 5505). It suggested that this is due to the proportion of LDHC4 from sources other than seminal sperms fraction becomes greater,and the higher proportion of nonmature sperms in semen was one of possible reasons for the increased activity of LDHC4 in the users of TW.

关 键 词：雷公藤 人精液 LDHC4 同功酶 

分 类 号：R285.6[医药卫生—中药学]