纸片法脐带血人促甲状腺激素放免分析筛查新生儿甲状腺功能低下症  

CORD BLOOD-SPOT THYROTROPIN RIA IN A SCREENING PROGRAM FOE CONGENITAL HYPOTHYROIDISM

作　　者：陈昆明[1] 张墨玲[1] 马丽云[1] 方佩华[1] 袁承运[1] 田恩仁 

机构地区：[1]天津医学院内分泌研究所 [2]天津医学院免疫研究室

出　　处：《中国地方病防治》1989年第3期143-146,共4页Chinese Journal of Control of Endemic Diseases

摘　　要：本文报告了干血点纸片法人促甲状腺激素(h-TSH)放免测定法,以及用脐带血纸片样品进行新生儿先天性甲状腺功能低下症(简称甲低)筛查的检测程序,用此方法及程序对28503例新生儿脐血纸片筛查结果表明:永久性原发性甲低发病率为1/5919(5例);一过性甲低4例;复检率为0.59%;2949例脐血纸片样品和8018例脐血血清样品h-TSH测定结果比较二者测定值频数分布状态极为相似,筛查实践证明脐血纸片法在新生儿甲低筛查工作中是可行的。A screenig program for congenital hypothyroidism using dried cord bloo d-spot is reported. By this method, analysis of variance of cordspot TSH distribution in 2949 cases were done; 138 neonatal normal value and 127 adult TSH evel were observed. 28503 babies were screened at the screening LAB in Tianjin Medical College. An congenital hypothyroidism incidence of 1:5919, (5 cases)was found. Our result shows the dried cord blood-spot screening method may be effective and satisfactory in practice.

关 键 词：促甲状腺激素 放免分析 甲状腺功能 

分 类 号：R581.204[医药卫生—内分泌]