新生牛肝细胞生长因子的活性研究──Ⅱ.新生牛肝细胞生长因子对大鼠急性肝损伤的保护作用  被引量:9

THE STUDY ON THE ACTIVITY OF HGF FROM NEW BORN CATTLE LIVER──Ⅱ .THE CURATIVE EFFECTS OF HGF ON FULMINANTHEPATIC FAILURE INDUCED BY CCI. IN RATS

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作  者:张振宇[1] 姜世明[1] 徐朝晖[1] 陈建国[1] 潘沛恩[1] 张琴冈[1] 岳凤娥[1] 王兆红[1] 程华[1] 

机构地区:[1]山东师范大学生物系,山东中医学院,济南市传染病医院

出  处:《山东医科大学学报》1995年第3期206-209,共4页Acta Academiae Medicinae Shandong

摘  要:研究了新生牛肝细胞生长因子(cHGF)对CCl4引起的大鼠急性肝损伤的保护作用。结果表明,cHGF可降低CCl4引起的急性肝衰竭大鼠的死亡率,抑制血清谷丙转氨酶(GPT)和胆红素(Bil)的升高。从肝组织切片观察到cHGF可明显减轻CCl_4引起的肝细胞结构的损伤,证实HGF是一种有效的保肝活性因子。A hepatocyte growth factor (HGF) was extracted from new born cattle liver. The Wistar rats were intraperitoneally (i.p.) injected with carbon tetrachloride (in soybean oil) at a dose of 4ml/kg body weight to induce hepatic injuries and the protective effect of HGF on thus induced hepatic damage was investigated. The results were as follows: l.HGF could decrease the death rate from 80% to 20%. 2.Hepatic histological findings indicated that the degree of CCl4 -induced hepatic lesions could be lessened by HGF. 3.HGF could suppress the elevation of sGPT and sBil induced by carbon tetrachloride intoxication.The results suggest that HGF is a potential active factor for protecting liver .

关 键 词:肝细胞生长因子 肝疾病 四氯化碳  大鼠 

分 类 号:R512.6[医药卫生—内科学]

 

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