海南省陵水及白沙等地区恶性疟原虫对磷酸喹哌的敏感性调查  

IN VIVO SENSITIVITY OF PLASMODIUM FALCIPARUM TO PIPERAQUINE PHOSPHATE ASSAYED IN LINSHUI AND BAISHA COUNTIES, HAINAN PROVINCE

作　　者：蓝昌雄 林秀 黄在松 陈玉松[2] 郭仁能 

机构地区：[1]海南省第二寄生虫病防治研究所 [2]白沙县卫生防疫站

出　　处：《中国寄生虫学与寄生虫病杂志》1989年第3期1-1,共1页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：1986年7～12月,在海南省陵水县吊罗山、白沙县元门乡、青松乡及三亚市南滨农场,治疗恶性疟病人53例,采用磷酸喹(?)1.5g(碱基),3d分服,退热时间为36.0±20.7h,原虫转阴时间为69.7±20.9h。治疗后经14、21和28d随访者47例,发现一级抗性7例,复燃率14.9％,治疗后带配子体者35例,配子体率74.5％,较以往报告的57.1与40％为高。Fifty-three cases of falciparum malaria in Linshui County, Baisha County and Sanya Municipality were treated with piperaquine phosphate at a total dose of 1.5gbase over 3 days in July to December, 1986. The mean defervescence time was 36±20.7h; the mean asexual parasite clearance time was 69.7±20.9h. At 14-28d follow-up lecrudescence was observed with asexual parasitemia in 7 of the 47 cases, showing RI resistance to piperaquine. Gametocytemia was positive in 35 cases (74.5%) during the follow-up period.

关 键 词：疟原虫 磷酸硅哌 敏感性 

分 类 号：R978.62[医药卫生—药品]