皮内试验应用于丝虫病纵向监测的评价  

ASSESSMENT OF INTRACUTANEOUS TEST IN LONGITUDINAL SURVEILLANCE FOR LYMPHATIC FILARIASIS

作　　者：石福田 蔺西萌[2] 施恒华[1] 黄倩[2] 史宗俊[1] 

机构地区：[1]中国预防医学科学院寄生虫病研究所 [2]河南省卫生防疫站

出　　处：《中国寄生虫学与寄生虫病杂志》1989年第4期280-283,共4页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：以犬恶丝虫提纯多肽抗原(FPT)皮内试验(IT)为免疫学监测方法,对河南省确山县班氏丝虫病流行区观察点人群丝虫特异性免疫水平在海群生治疗前后的动态变化进行纵向观察。经海群生有效治疗后,人群速发型超敏反应水平呈明显下降趋势。以调查人群速发型超敏反应阳性率、强阳性反应出现频率及追踪观察人群速反型超敏反应转阳率等三项指标综合评价能较好地反映出特定时段内丝虫病传播状况及传播趋势。In order to evaluate the usefulness of intracutaneous test (IT) in longitudinal sur-veillance of filariasis, two administrative villages selected from Queshan County, Henan Province of China, endemic for Wuchereria bancrofti, were surveyed in 1982, 1983 and 1987 respectively. by IT with antigen FPT derived from Dirofilaria immitis.The result showed that the original level of IT to antigen FPT in the population was consistent with the data of either etiological or entomological investigation before chemotherapy. When the microfilaraemia rate and naturall filarial infection rate of mos-quitoes in a village were high, the positive rate and frequency of strong positivity (skin wheel diamater≥1.3mm) for immediate hypersensitivity reaction would be high too; and the reverse was true. It is suggested that both criteria of IT mentioned above may be useful in assessing endemicity of lymphatic filariasis before mass chemotherapy.The speed of negative conversion of IT in both groups, the previously microfilarae-mic patients and the amicrofilaraemic inhabitants positive to immediate hypersensitivity reaction before chemotherapy, were different, the former being significantly slower than that of the latter after mass and selective chemotherapy with diethylcarbamazine.AU of the three criteria for immediate hypersensitivity, positive rate, frequency of strong positivity and positive conversion rate, decreased gradually after a mass and selective DEC treatment. Until 1987, the 5th year after the chemotherapy, the average positive rate in the two villages dropped to 20.0% from 55.4% in 1982, the frequency of strong positivity to 2.8% from 23.8% in 1982, and the positive conversion rate to 9.7% (1984-1987) form 19.2% (1982-1983). This result indicated that the three criteria of IT reflect not only the status but also the trend of filariasis transmission after chemotherapy in an endemic area, and may be also useful in longitudinal seroepidemiological surveillance of lymphatic filariasis.

关 键 词：皮内试验 丝虫病 监测 

分 类 号：R532.15[医药卫生—内科学]