MPTP增加脑糖代谢与Deprenyl对其拮抗作用的实验研究  

The Increase of Regional Cerebral Glucose Metabolism Induced by Methyl-phenyl-tetrahydropyridine and Prevented by Deprenyl: Experimental Study

作　　者：陈生弟[1] 徐德隆[1] 周孝达[1] 钱可久[1] 

机构地区：[1]上海第二医科大学附属瑞金医院神经科,上海第二医科大学附属仁济医院神经科

出　　处：《上海第二医科大学学报》1995年第1期10-13,共4页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：应用［３Ｈ］２－ＤＧ放射自显影法观察ＭＡＯ－Ｂ抑制剂Ｄｅｐｒｅｎｙｌ和神经毒素ＭＰＴＰ对小鼠脑２－ＤＧ摄取的影响。腹腔注射ＭＰＴＰ后，模型组鼠的黑质和蓝斑区的２－ＤＧ摄取量较对照组鼠明显增加，并表现出明显的行为异常反应。预先口服ｄｅｐｒｅｎｙｌ的拮抗组鼠，２－ＤＧ摄取量与对照组相同，且行为反应轻微。结果表明ＭＰＴＰ对小鼠黑质和蓝斑区的局部糖利用有明显的影响；Ｄｅｐｒｅｎｙｌ能有效地防止ＭＰＴＰ，的这一有害作用。H-2-deoxyglucose(2-DG) autoradiographic technique was used to study the effects of deprenyl, a monoamine oxidase-B(MAO-B) inhibitor and the neurotoxin methyl-phenyl-tetrahydropyridine(MPTP) on 2-DG uptake in the mouse brain. Following MPTP intoxication,2-DG uptake was increased in the substantia nigra and locus ceruleus.At the same time, Obvious abnormal behavior of the animals was induced. In the mice pretreated with deprenyl,2-DG uptake was similar to that of the control animals. Abnormal behavior, though present, was significantly milder than in the miee given MPTP alone. It is concluded that MPTP inteiferes with glucose metabolism in the substantia nigra and locus ceruleus and induees the remarkable abnormal behavior syndrome in mice. These deleterious effects can be blocked by pretreatment with deprenyl.

关 键 词：神经毒素 四氢吡啶 MPTP DEPRENYL 震颤性麻痹 

分 类 号：R994.3[医药卫生—毒理学] R742.502[医药卫生—药学]