溶脲脲原体人工感染引发大鼠膀胱结石  

Calculus of Rat Bladder Induced by Ureaplasma Urealyticum Inoculation

作　　者：孙广芳[1] 徐晨[1] 王一飞[1] 

机构地区：[1]上海第二医科大学

出　　处：《上海实验动物科学》1995年第2期79-81,共3页Shanghai Laboratory Animal Science

摘　　要：１００只２．５月龄清洁级ＳＤ雄性大鼠分为３组：Ａ组４５只，Ｂ组２２只，Ｃ组３３只。Ａ组大鼠膀胱内注入血清８型溶脲脲原体菌株Ｔ９６０；Ｂ组除与Ａ组同样处理外，且在接种后３个月给予美满霉素（２０～１００ｍｇ／ｋｇ），连续１４ｄ；Ｃ组为对照组，每只动物给予等量溶脲脲原体液体培养基。结果：Ａ组８７．５％、Ｂ组２０％的动物膀胱组织的溶脲脲原体培养阳性，Ｃ组为阴性；Ａ、Ｂ两组有极显著差异（Ｐ＜０．００１），表明美满霉素能有效地抑制溶脲脲原体。Ａ组膀胱结石检出率为４０％，Ｂ组为３５％，Ｃ组为零；Ａ、Ｂ两组无明显差异（Ｐ＞０．１）。One hundred SD male rats were randomly divided into 3 groups: group A, 45 rats, ureaplasma urealyticum(u. u. ) were inoculated into the bladders: group B, 22 rats, in addition to the inoculation of u. u., minomycin(20-100 mg/kg,day) was administrated for 14 days 3 months after the inoculation; group C. 33 rats as the control. The results showed that (1) the u. u. infective rates were 87 .5%. 20%and 0% for group A, B and C respectively (P<0 .001, group A versus group B);(2) the incidences of bladder calculus were 40%, 35% and 0% for group A, B. C respectively (P>0. 1, group A versus B). The possible relationship between bladder. calculus and u. u. infection was discussed.

关 键 词：溶脲脲原体 膀胱结石 大鼠 动物模型 

分 类 号：R694.4[医药卫生—泌尿科学]