甲硝唑经小鼠离体皮肤的透皮吸收  

TRANSDERMAL ABSORPTION OF METRONIDAZOLE THROUGH MICE SKIN IN VITRO

作　　者：徐予猷 舒微[1] 吴怀瑛[1] 

机构地区：[1]上海医科大学药学院物理化学教研室

出　　处：《上海医科大学学报》1995年第2期145-147,共3页Journal of Fudan University(Medical Science)

摘　　要：采用Ｖ－Ｃ水平扩散池研究甲硝唑对经不同条件处理后的小鼠离体皮肤的穿透传 性，比较几种常用透皮促进剂对甲硝唑穿透率的影响。实验结果显示：去角质层皮肤将大大提 高甲硝唑的穿透率；冰冻２周后的鼠皮对甲硝唑的穿透率尚无影响；在１０％丙二醇溶液中，经 过 ３０ ｈ的扩散试验， １％氮酮可显著增加甲硝唑的透皮速率 １０倍以上。V-C horizontal diffusion cell was used to study the permeability of mouse skin treated under different conditions. We compared the permeability of metronidazole (MTZ) in several often-used enhancers. The results indicated the permeabilities of MTZ were greatly raised with stripped mouse skin and not influenced in the frozen mouse skin stored for two weeks. The permeability in 10% propylene glycol solution during the first 30h of the diffusive experiments was increased about 10 times in 1% azone.

关 键 词：甲硝唑 透皮吸收 穿透率 

分 类 号：R978.6[医药卫生—药品]