硒化卡拉胶胶囊在兔体的生物利用度  

BIOAVAILABILITY OF SELENOCARRAGEENAN CAPSULE IN RABBITS

作　　者：张建芳[1] 徐惠南[1] 吕玉真 翁伟宇[1] 曹志 李巧云[1] 

机构地区：[1]上海医科大学药学院药剂学教研室

出　　处：《上海医科大学学报》1995年第2期143-144,共2页Journal of Fudan University(Medical Science)

摘　　要：用荧光分光光度法测定硒化卡拉胶（硒宝康）胶囊在兔体内的生物利用度。结 果：血Ｓｅ达峰时间（ｔｍａｘ）５．０５ ｈ，最大峰浓度（Ｃｍａｘ）１１５．２９μｇ／Ｌ，药时曲线下面积（ＡＵＣ０→２４） １６４８．７９μｇ·Ｌ－１·ｈ。结论：硒宝康胶囊的生物利用度较亚硒酸钠胶囊大，两种含硒药物间有显 著差异（Ｐ＜０．０５），前者维持时间也较长，是一优于亚硒酸钠胶囊的补硒制剂。After oral administration with selenocarrageenan capsule (each containing 50μg, xinbaokang capsule)in rabbits, the bioavailability and pharmacokinetic parameters compared to sodium selenite capsule were determined by fluorscence. The results: tmax, Cmax and AUC0→24. of xibaokang were 5. 05h, 115.29μg/L and 1 648.69μg.L-1.h. The bioavailability of xibaokang capsule was 1.51 times higher than that of sodium selenite capsule. The results indicate that xibaokang had better bioavailability and longer effect time than sodium selenite capsule.

关 键 词：硒化卡拉胶 硒宝康 生物利用度 

分 类 号：R977.5[医药卫生—药品]