自主性甲状腺结节的高功能与TSH受体的敏感性及Gs/Gi蛋白功能特性的关系  

THE HYPERFUNCTION OF THYROID AUTONOMOUS NODULE IS HIGHLY ASSOCIATED WITH SENSITIVITY OF TSH RECEPTOR AND FUNCTIONAL CHARACTERISTICS OF Gs/Gi

作　　者：贺铭[1] 杨永年[1] 

机构地区：[1]上海医科大学中山医院内分泌科

出　　处：《上海医科大学学报》1995年第2期105-108,共4页Journal of Fudan University(Medical Science)

基　　金：国家自然科学基金!(38970385)资助

摘　　要：通过测定基础状态、ＴＳＨ和（或） ＧＴＰγｓ刺激后组纯化的甲状腺细胞膜蛋白腺苷酸环化酶（ＡＣ）活力，发现５例非功能性甲状腺肿瘤（ＮＦＴＴ）在以上三种情况下的ＡＣ活力与 其周围正常组织无差异，而４例自主功能性甲状腺结节（ＡＦＴＮ）的ＡＣ活力均高于其周围组织，表明 ＡＦＴＮ的高功能的形成与ＴＳＨ受体的敏感性增高和Ｇｓ／Ｇｉ蛋白的活性及量的改变以及表现为Ｇｓ的功能特性增强有关。Partially purified plasma membrane preparations of neoplastic and normal thyroid tissue were used to measure adenylate cyclase (AC) activity in basic, TSH or/and GTPγs stimulated condition. The AC activity indicated above in five cases of non-functioning thyroid tumours was not different from that of in their adjacent normal tissues, while it was significant increase in four eases of auton- omously functioning thyroid nodules(AFTN) compared to that of their adjacent normal tissues. This demonstrated that the high function of AFTN appears to be associated with the high sensitivity of TSH receptor and the increase of constitutional activity and amount of Gs/Gi protein in general.

关 键 词：甲状腺结节 受体 G蛋白 促甲状腺激素 

分 类 号：R581.02[医药卫生—内分泌]