特发性肺纤维化肺功能测定与激素治疗  

LUNG FUNCTION TESTS AND CORTICOSTEROID THERAPY IN IDIOPATHIC PULMONARY FIBROSIS

作　　者：郑金旭[1] 贾友明[1] 蔡映云[1] 董鹤嘉[1] 翁曼蓉 张志凤[1] 张新[1] 

机构地区：[1]上海医科大学中山医院肺科

出　　处：《上海医科大学学报》1995年第2期109-112,共4页Journal of Fudan University(Medical Science)

摘　　要：测定并分析５８例特发性肺纤维化的肺功能各项指标，包括１５例激素治疗后肺功 能改变的资料。发现特发性肺纤维化的肺功能特点为：肺容积减少，限制性通气功能障碍及弥 散功能障碍。部分病人出现低氧血症。激素治疗可使肺功能得以改善，有效率达６０％以上；病 程短（≤３月）的病例，肺功能好转率尤为增高（Ｐ＜ ０．０５）。在各项指标中，以 ＶＣ、 ＤＬｃｏ和 ＰａＯ２等三项指标在治疗后变化明显。初步结论；肺功能检测对辅助诊断特发性肺纤维化和评 价激素疗效，均有重要的临床价值。Lung function test were analysed in 58 cases of idiopathic pulmonary fibrosis (IPF), and in 15 patients showing response to corticosteroid therapy. The results were (1) reduction in lung volume (VC, TLC) and diffusing capacity DLco) , with hypoxemia in some patients; (2) corticosteroid therapy showed improved lung function in 60% of patients, especially in early stages(≤3 month) of the disease (P<0.05), in the VC, DLco and PaO2 parameters. These results indicate the usefulness of lung function tests in the diagnosis of IPF and the value of corticosteroid therapy.

关 键 词：肺功能 肺纤维化 肾上腺皮质激素 药物治疗 

分 类 号：R563.05[医药卫生—呼吸系统]