急性心肌缺血早期血清钾、镁含量变化与心律失常的实验观察  

EXPERIMENTAL OBSERVATION ON THE VARIATIONS OF CONTENTS IN SERUM POTASSIUM AND MAGNESIUM WITH ARRHYTHEMIA DURING EARLY PERIOD OF ACUTE MYOCARDIAL ISHEMIA

作　　者：郁礼兴[1] 徐伟珍[1] 董惠芳[1] 

机构地区：[1]上海中医药大学生理教研室,上海中医药大学附属曙光医院检验部

出　　处：《上海医学》1995年第6期318-321,共4页Shanghai Medical Journal

摘　　要：作者观察了采用结扎冠脉左前降支造成１９只家兔急性心肌缺血实验模型，于不同时间段动态检测血清钾和镁含量变化，结果显示１１只家兔在心肌缺血后最初８０分钟内低血钾、其与对照值比较存在显著差异（Ｐ＜０．００１），其中２只家兔（１０．５％）并发室性心动过速；此外，发现３只家兔血镁含量轻度降低。作者认为急性心肌缺血早期的低血钾可诱发室速、室颤，易导致猝死。低血钾的产生主要由于交感－儿茶酚胺系统紧张性增高所致。Abstract In this study we made an experimental model of acute myocardial ischemia causedby occlusion of anterior desending branch of left coronary artery in 19 rabbits, thecontents of potassuim ions(K￣+) and magnesium ions(Mg￣(++))in 140 minutes were mea-sured serially. The result showed that there was a hypopotassemia in 11 rabbits atfirst 80 minutes after acute myocardial ischemic attack. There was a great differencebetween acute myocardial ischemia and control value(P<0.001)and 2 of 11 rabbitswere complicated with ventricular tachycardia(10.5%). In addition, a slight hypo-magnesemia was observed in 3 rabbits. The authors consider that the hypopotassemia during early period Of acute myo-cardial ischemia may easily cause sudden death to the animal due to ventricular tachy-cardia and ventricular fibrillation. The hypopotassemia may be mainly caused by in-creased tone in sympathetic-catecholamine system.

关 键 词：心肌缺血 钾 镁 心律失常 

分 类 号：R541.402[医药卫生—心血管疾病]