地塞米松、甲状腺素对大鼠胎肺表面活性物质影响及机制的初步研究  

THE PRELIMINARY STUDY OF EFFECTS AND MECHNISM OF DEXAMETHASONE AND THYROXINE ON PULMONARY SUEFACTANT OF RAT FETAL LUNG EXPLANTS

作　　者：王晓川[1] 金勤立[1] 沈惟堂[1] 夏绿蒂[1] 盛民立[1] 

机构地区：[1]上海医科大学儿科医院儿科研究所,上海医科大学放射医学研究所

出　　处：《上海医学》1995年第7期388-391,共4页Shanghai Medical Journal

基　　金：国家自然基金

摘　　要：本文用大鼠胎肺组织块无血清培养观察地塞米松（Ｄｅｘ）、甲状腺素（Ｔ＿４）对大鼠胎肺表面活性物质（ＰＳ）的作用特点。Ｄｅｘ效应在胚胎１８、１９天最显著，并随Ｄｅｘ浓度增加而增高，但高浓度Ｄｅｘ对胎肺糖皮质激素受体（ＧＣＲ）有向下调节作用。Ｔ＿４可促进ＰＳ增加，并与Ｄｅｘ有协同作用，对胎肺ＧＣＲ有向上调节作用。本文为临床合理应用Ｄｅｘ或联合Ｔ＿４预防新生儿呼吸窘迫综合征提供实验基础。he effects of dexamethasone and thyroxine on the pulmonary surfactant of fetalrat lung explants were studied in vitro. It mainly occured in 18 or 19 days of rat ges-tational age that the maturation of pulmonary surfactant of the lung explants was sti- mulated by dexamethasone.The effects of dexamethasone were also dose-dependent. Butthe specifc binding of cytoplasmic glucocorticoid recepter of 18 days fetal rat lungcxplants was decreased according to the increased concentration of dexamethasone(down- regulation).Thyroxine also inereased the pulmonary surfactant,and the pulmonary sur- factant was increased,being treated dy both dexamethasone and thyroxine,more thaneither alone.At least in part.this might be caused by the up-regulation of thyroxineon glucocorticoid recepter.

关 键 词：地塞米松 甲状腺素 肺表面活性物质 糖皮质激素 

分 类 号：R963[医药卫生—微生物与生化药学]