尿中前列腺素变化在肾移植排异反应中的诊断价值  

Urinary excretion of prostaglandins in nor-mal subjects and patients with renal allo-graft rejection

作　　者：余学清[1] 吴培根[1] 沈清端[1] 

机构地区：[1]广州中山医科大学肾脏研究所

出　　处：《肾脏病与透析肾移植杂志》1995年第2期131-133,共3页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：为了探讨肾移植术后尿中前列腺素的变化及其临床意义，我们测定了３４例肾移植术后患者（其中１１例伴有急性排异反应）、１６例尿毒症患者尿中前列腺素的变化。结果显示，肾移植术后尿中６－ｋｅｔｏＰＧＦ１α（６－酮前列腺素Ｆ１α）降低，ＴＸＢ２（血栓素Ｂ２）增高，随着肾功能的改善，二者均渐恢复正常。急性排异反应者尿６－ｋｅｔｏＰＧＦ１α降低及ＴＸＢ２升高更为显著，尤其是ＴＸＢ２较肌酐升高早而显著，并随着排异反应的控制而降低。上述结果表明，尿中前列腺素的变化，尤其是ＴＸＢ２的变化是监测肾移植早期排异反应的较好指标。n order to investigate the clinical sig-nificance of urinary prostaglandins in acuterenal allograft rejection, thromboxane B2( TXB2)and 6-keto PGF1a were measured indaily urine samples from 34 patients afterrenal transplantation (11 of 34 patients withacute renal allograft reJection) . 16 patientswith uremia and 20 health subjects. Bothurinay 6-keto PGF1a and TXB2 were gradual-ly normal becoming in the patients after re-nal transplantation. Decreased 6-keto PGF1aand increased TXB2 were found in the acuteallogragt rejection episodes. The increase inurinary TXB2 preceded the change of serumcreatuiuie and the clinical diagnosis of rejec-tion. The above results show that uruiaryTXB2 and 6-keto PGF1a may be an early in-dicator of acute renal allograft rejection.

关 键 词：肾移植 排异反应 前列腺素 尿 

分 类 号：R699.2[医药卫生—泌尿科学]