多巴胺参与P物质对胃肌电活动和胃运动的毒蕈碱抑制效应  

PARTICIPATION OF DOPAMINE ON THE NUSCARINERGIC INHIBITORY EFFECT OF SUBSTANCE P ON GASTRIC MYOELECTRIC ACTIVITY AND MOTILITY

作　　者：荆浩[1] 林坤伟[1] 梅懋华[1] 

机构地区：[1]大连医科大学生理教研室

出　　处：《生理学报》1995年第3期245-252,共8页Acta Physiologica Sinica

基　　金：国家自然科学基金

摘　　要：我们以前的工作表明尾核注射Ｐ物质能抑制胃肌电快波和胃运动，该效应是通过胆碱能Ｍ受体介导的。本文观察到Ｐ物质的抑胃效应可分别被尾核注射Ｐ物质抗血清、Ｐ物质受体拮抗剂［Ａｒｇ６，Ｄ－Ｔｒｉｐ７，９，ＭｅＰｈｅ８］－ＳＰ６－１１以及多巴胺Ｄ２受体阻断剂氟哌啶醇所消除；尾核注射多巴胺对胃肌电快波和胃运动也有抑制作用，且能被尾核注射氟哌啶醇以及阿托品所阻断。据此，我们设想尾核Ｐ物质可能是通过多巴胺Ｄ２受体兴奋胆碱能Ｍ受体实现其抑制胃肌电快波和胃运动的效应。Our previous study showed that microinjection of substance P (SP) into caudate nucleus inhibits gastric myoelectric fast wave and gastric motility, an effect mediated by muscarinic receptor. The present investigation showed that this effects of SP could be blocked by coinjected SP antiserum or SP antagonist [Arg6, D-Trip7,9, MePhe8] SP6-11 or D2 dopamine antagonist haloperidol. In addition, microinjection of dopamine (DA) into caudate nucleus could also inhibit gastric fast wave and motility, an effect agsin being blockable by coinjected DA antagonist haloperidol or atropine. Thus, it appears that the muscarinergic inhibitory effect of SP on gastric fast wave and motility is mediated by D2 dopamine receptor.

关 键 词：胃肌电活动 胃运动 P物质 多巴胺 尾核 

分 类 号：R333.2[医药卫生—人体生理学]