吗啡的精神神经免疫学作用及灵芝多糖肽对吗啡依赖小鼠的免疫保护效应  

Psychoneuroimmunological Effects of Morphine and the Immunoprotection of Ganoderma Polysaccharides Peptide in Morphine-dependent Mice

作　　者：陆正武[1] 

机构地区：[1]北京医科大学药理学系

出　　处：《生理科学进展》1995年第1期45-49,共5页Progress in Physiological Sciences

摘　　要：通过多种急慢性吗啡给药动物模型，从整体、细胞和分子水平，系统研究了吗啡的精神神经免疫学作用及灵芝多糖肽（ＧＰＰ）对吗啡依赖小鼠的免疫保护效应。首次发现：反复吗啡处理小鼠脾细胞内原癌基因ｃ－ｍｙｂ和ｃｍｙｃ的表达比正常动物降低；ＧＰＰ可以明显恢复吗啡处置小鼠降低的各项免疫学实验指标达到甚至超出对照水平，从而为应用ＧＰＰ等免疫反应修饰剂控制阿片滥用所致的免疫功能缺陷提供了动物实验依据。Different kinds of single, multiple, acute or chronic administrations of morphinized animal models were established, with which a series of experiments in both in vivo and in vitro systems as well as molecular levels were pharmacologically designed to investigate the psychoneuroimmunological effects of morphine(Mor)and the immunoprotection of Ganoderma polysaccharides peptide(GPP) in Mor-dependent mice.It was first discovered that both c-myb and c-myc e mRNA expression in splenocytes of repititive Mor-treated mice were detected to be significantly decreased, and that GPP could induce restoration of several immunologic parameters depressed by Mor treatment to or even beyond normal levels.This provides the experimental animal evidence that immune response modifiers such as GPP could be of potential application in controlling abuse of opiates-induced immunodeficiency.

关 键 词：吗啡 灵芝多糖肽 免疫功能 精神神经免疫学 

分 类 号：R967[医药卫生—药理学]