血管紧张素Ⅱ诱导左心室原癌基因c－fos和c－myc的表达  

ANGIOTENSIN Ⅱ INDUCES C-FOS AND C-MYC PROTO-ONCOGENE EXPRESSION IN THE LEFT VENTRICLE

作　　者：陈伟红[1] 谭定定[1] 潘敬运[1] 胡本荣[1] 

机构地区：[1]中山医科大学受体研究室

出　　处：《生理学报》1995年第1期59-64,共6页Acta Physiologica Sinica

基　　金：国家自然科学基金;中华医学基金

摘　　要：本实验用Ｌａｎｙｅｎｄｏｒｆｆ心脏灌流装置，探讨血管紧张素Ⅱ对左心室原癌基因ｃ－ｆｏｓ和ｃ－ｍｙｃ表达的作用。观察到血管紧张素Ⅱ能诱导左心室ｃ－ｆｏｓ和ｃ－ｍｙｃ的表达，ｃ－ｆｏｓ表达早于ｃ－ｍｙｃ表达，并呈量－效关系。这种作用可被血管紧张素Ⅱ受体拮抗剂ｓａｒａｌａｓｉｎ所阻断。这些结果提示血管紧张素Ⅱ诱导的ｃ－ｆｏｓ和ｃ－ｍｙｃ的表达是受体介导的。ＴＴＸ完全阻断血管紧张素Ⅱ诱导的ｃ－ｆｏｓ表达。ＴＴＸ对ｃ－ｍｙｃ的表达无明显影响。In the present study, the effects of angiotension Ⅱ on the expression of protooncogene c-fos and c-myc in the left ventricle were investigated on Langedorff heartpreparations. It was observed that angiotensin induced both c-fos and c-myc expressionin a dose-dependent manner and the c-fos expression showed an earlier appearance thanc-myc. All these induced expressions were blocked by a Angiotensin Ⅱ receptor antagonist saralasin. The Angiotensin Ⅱ induced expression of c-fos was also blocked byTTX, but the c-myc gene expression was unaffected.

关 键 词：血管紧张素Ⅱ C-FOS C-MYC 心肌肥厚 原癌基因 

分 类 号：R542.202[医药卫生—心血管疾病] R972.5[医药卫生—内科学]