阿的平调节β－肾上腺素受体、膜磷脂代谢及预防热损伤的研究  

PREVENTIVE EFFECT OF QUINACRINE ON THE DEVELOPMENT OF HEAT INJURY BY STABILIZING MEMBRANE PHOSPHOLIPIDS METABOLISM AND β-ADRENOCEPTOR

作　　者：邢成[1] 吕宝璋[1] 王鲁明[1] 单京瑞 刘永学[1] 

机构地区：[1]军事医学科学院基础医学研究所

出　　处：《生理学报》1995年第1期11-18,共8页Acta Physiologica Sinica

基　　金：国家自然科学基金

摘　　要：以前研究表明，热应激可使大鼠肺组织细胞膜肾上腺素能受体明显下调、膜磷脂分解代谢加速。本研究观察了阿的平（磷脂酶Ａ２的非特异性抑制剂）对β－肾上腺素受体及膜磷脂代谢的调节作用和对机体热损伤的防护作用。结果表明，阿的平对热应激造成的β－受体的下调、磷脂分解的加速具有明显的抑制作用，并能明显提高大鼠和人对热应激的耐受能力。Previous Studies have demonstrated that the activation of phospholipase A2(PLA2 ) during heat stress would caused disorder of membrane phospholipids metabolism, accompanied by a decrease in phosphatidylcholine and phosphatidyl-serineand an increase in arachidonic acid. In heat stressed rats, a down-regulation of β-adrenergic receptor in lung tissue was observed due to activation of PLA2. In the Present work, it was demonstrated that pretreatment of rats with PLA2 inhibitor, quinacrine (20 mg/kg, I. P. ), 1 h before heat stress could block these membrane lipid alterations,and the tolerance of rats to heat exposure was enhanced. The effect of quinacrine onthe thermotolerance of marching solidiers with 15 kg of load under hot environmentwas also investigated. The results indicated that in the soldiers taken orally 200 mg quinacrine 1 h before marching, their heart rate, body temperature, accumulation of blood lactic acid and the changes of index of heart function were significantly improved as compared to the control group at the end of 3 h marching. According to these data,it can be concluded that quinacrine is a useful drug to prevent derangement of β-adrenoceptor and mepsbrane phospholipids metabolism in the development of heat stress. So asto prevent heat injury, and to improve tolerance to heat stress.

关 键 词：阿的平 热损伤 膜磷脂 Β肾上腺素受体 药理学 

分 类 号：R979.4[医药卫生—药品] R965[医药卫生—药学]