脑室注射NE对室旁核神经内分泌大细胞的作用  

EFFECTS OF INTRACEREBROVENTRICULAR ADMINISTRATION OF NOREPINEPHRINE ON PARAVENTRICULAR NEUROSECRETORY CELLS

作　　者：纪亚平[1] 梅俊[1] 唐斌 

机构地区：[1]西安医科大学脑和神经研究室

出　　处：《生理学报》1995年第2期120-126,共7页Acta Physiologica Sinica

摘　　要：在成年ＳＤ大鼠上，用玻璃微电极进行细胞外记录，结合逆行鉴定技术确定下丘脑室旁核神经内分泌大细胞，并观察其对去甲肾上腺素的反应。在４９个逆行鉴定神经元中，位相型，快连续型及慢不规则型放电单位分别占４２．９％，３６．７％及２０．４％。脑室内注射去甲肾上腺素（０．２μｇ／μｌ）对位相型单位主要产生抑制作用，对快连续及慢不规则单位主要为兴奋作用。脑室内注射酚妥拉明（２μｇ／μｌ）能部分拮抗ＮＥ对位相型神经元的抑制。结果表明：ＮＥ对室旁核中不同类型放电单位作用不同，其对位相型单位抑制作用可能由α受体参与介导。Extracellular electrical activities of paraventricular nucleus (PVN) cells were recorded in anaesthetized adult rats by using glass microelectrodes. After antidromical identification of the magnocellular neurosecretory cells, the effects of intracerebroventricular (i. c. v. ) injection of norepinephrine (NE) on such cells were observed. Of 49 neurons of antidromic stimulation, phasic, fast continuous and slowly irregularly firing units constituted 42. 9 %, 36. 7 %, and 20. 4 % of the total population respectively. With i. c. v. injection, NE inhibited the activity of most phasically firing units, but enhanced that of most fast continuous and slowly irregular firing units. The inhibinon effect of NE could be Partially antagonized by i. c. v. injection of phentolamine (2μg/μl), showing that the effect is possibly mediated by α-receptor. The above find lugs indicate that NE plays different roles in different PVN magnocellular neurons havlug different patterns of firing activity.

关 键 词：下丘脑 室旁核 神经内分泌 去甲肾上腺素 

分 类 号：Q426[生物学—神经生物学] R338.27[生物学—生理学]