电刺激兔肾脏传入神经对血压、心率及加压素释放的影响  

EFFECT OF ELECTRICAL STIMULATION OF AFFERENT RENAL NERVE ON ARTERIAL BLOOD PRESSURE,HEART RATE AND VASOPRESSIN IN RABBITS

作　　者：吕敏[1] 魏顺光[1] 柴象枢[1] 

机构地区：[1]山东省医学科学院生理研究室,中科院上海生理研究所低氧开放实验室

出　　处：《生理学报》1995年第5期471-477,共7页Acta Physiologica Sinica

摘　　要：本工作以免为实验对象，观察电刺激肾脏传入神经（ＡＲＮ）对血压、心率、颈交感神经放电、以及加压素（ＡＶＰ）合成和释放的影响，并对ＡＲＮ进入中枢的通路作了观察。结果显示，电刺激ＡＲＮ可以引起血压下降、心率减慢、颈交感神经放电抑制等反应，ＡＲＮ的兴奋还可使下丘脑的视上核、室旁核中的ＡＶＰ含量增加，垂体中ＡＶＰ含量下降，血浆ＡＶＰ水平升高。硝普钠的降压实验和静脉注射ＡＶＰ受体阻断剂ＡＶＰａ的实验均证实了ＡＲＮ兴奋可直接引起ＡＶＰ释放的增加。通过去除迷走神经结状节、脊髓不同水平的横断等实验观察到免ＡＲＮ向中枢的投射途径可能是从Ｔ５—Ｌ２间进入脊髓并沿其上行的。The effect of electrical stimulation of afferent renal nerve (ARN) on cardiovascufar response, the synthesis and release of vasopressin were studied in rabbits. During the course of the experiment, the pathway of ARN to central nerve system was also analyzed. The results showed that electrical stimulation of ARN elicited significantly decrease of mean arteral blood pressure and heart rate as well as inhibition of cervical sympathetic nerve activity. In the event of the above physiological changes, the AVP concentration in supraoptic nucleus (SON), paraventricular nucleus (PVN) and plasma was increased, but that in hypophysis was decreased. Injection of sodium nitropruside (SNP) or AVPa indicated that increase of AVP release was due directly to stimulation of ARN. Nodose ganglionectomy or transversal section of spinal cord at different levels suggested that the main afferent pathway of ARN to higher level of central nerve system entered into spinal cord at T5-L2.

关 键 词：肾脏传入神经 加压素 血压 心率 

分 类 号：R338.3[医药卫生—人体生理学]