左旋千金藤啶碱对不同脑区DA更新率的影响  

EFFECT OF (-) STEPHOLIDINE ON DOPAMINE TURNOVER IN VARIOUS BRAIN REGIONS

作　　者：贺毓芳 黄开星[1] 金国章 

机构地区：[1]中国科学院上海药物研究所

出　　处：《生理学报》1995年第5期429-434,共6页Acta Physiologica Sinica

摘　　要：应用ＨＰＬＣ－ＥＣＤ测定ＤＡ更新率（ＤＯＰＡＣ／ＤＡ），证明（－）ＳＰＤ对黑质－纹状体、中脑－边缘系统、下丘脑－垂体ＤＡ神经系统的ＤＡ含量影响不明显，却显著增加ＤＯＰＡＣ含量，并显著加强这些脑区的ＤＡ更新率，这可能是通过末梢的ＤＡ自身受体实现的。但（－）ＳＰＤ既不显著影响中脑－前额叶和中脑－扣带回的ＤＡ含量，也不影响其中ＤＯＰＡＣ含量，表明它不影响这些脑区ＤＡ更新率。这可能是由于皮层ＤＡ系统神经末梢缺乏ＤＡ自身受体的缘故。It has been shown before that DA antagonist (-) stepholidine[(-) SPD] changes the function of feedback regulation in the striatum. In order to compare the effect of the drug on other brain DA systems, the DA content and DOPAC level in brain areas or nuclei of rat were measured by HPLC--ECD. It was found that (-) SPD (10 mg/kg, ip) did not significantly affect the DA contents in the striatum, olfactory bulb, N. accumbens, substantia nigra, ventral tegmentum area, N. amygdala, hypothalamus, pituitary, piriform cortex, but did markedly increase the DOPAC levels in these brain areas or nuclei, and thus increase the DA turnover (DOPAC/DA). However, (-) SPD (10 mg/kg, ip) did not significantly affect either the DA contents or DOPAC levels in the pre frontal cortex and cingulate cortex, thus leaving the DA turnover in these areas unchanges. These results indicated that (-) SPD did affect the nigro-striatal, midbrainlimbic and hypothalamus-pituitary DA systems, but not the midbrain-cortex DA system. It is supposed that this difference may be due to the modulation by presynaptic DA autoreceptors in the major brain areas of DA nerve endings or neurosoma, but none in the cortex DA nerve endings.

关 键 词：左旋千金藤啶碱 脑 多巴胺 更新率 药理学 

分 类 号：R965[医药卫生—药理学]