酯肽类抗生素547C的研究  

STUDIES ON THE DEPSIPEPTIDE ANTIBIOTIC 547C

作　　者：王沁[1] 吴林森[1] 徐生林[1] 蔡顺养 陈肖庆 

机构地区：[1]四川抗菌素工业研究所

出　　处：《中国抗生素杂志》1989年第3期204-207,共4页Chinese Journal of Antibiotics

摘　　要：从四川省康定地区土壤中筛选到一株链霉菌547.经形态、培养特征、生理生化特性研究,认为与已知蛎灰链霉菌接近。从547菌株发酵液中分离到抗生素547C,经理化特性、紫外光谱、红外光谱,核磁共振谱、质谱、氨基酸分析等研究,证实与维及尼霉素M_1同质。A strain of Streptomyces NO. 547 was isolated from a soil sample collected from Kangding prefecture, Sichuan Province. A depsipeptide antibiotic 547C was isolated from its fermentation broth. The aerial mycelium of the producing strain is straight. Through electron-microscopic observation, the spore surface is spiny. Its culture characteristic is very conformable with Streptomyces ostreogriseus in mor- phology described in the literature, but different from this known species and varieties in cultural and physiological characters. The physico-chemical properties.e. g. UV, IR, H-NMR, C-NMR as well as EI-MS of Antibiotic 547C are identical with data of Virginiamycin M, reported in the literatures. Antibiotic 647C posseses strong action on Gram positives and Hela cells in vitro. The LDBO lOOmgAg mouse (i. p.).

关 键 词：酯肽类抗生素 维及尼霉素 理化特性 

分 类 号：TQ465.92[化学工程—制药化工]