YPV-I型牦牛心包瓣替换二尖瓣术后远期的临床观察  

Long-term Clinical Observatoion of Mitral Valve Replacement With YPV-I Yak Pericardial Bioprosthesis

作　　者：肖锡俊[1] 石应康[1] 田子朴[1] 袁宏声[1] 梁绍伟 池雷延 唐兰珍[1] 

机构地区：[1]华西医科大学附属一院胸心外科

出　　处：《生物医学工程学杂志》1995年第1期24-26,共3页Journal of Biomedical Engineering

摘　　要：ＹＰＶ－Ｉ型瓣膜是一种血流动力学优良的牦牛心包瓣，但其耐久性和长期结果尚不知道。从１９８５年５月至１９８７年９月，我科使用该种瓣作二尖瓣替换。对５５例出院患者进行了随访。共随访３７９．４病人－年（平均６．９病人－年）。随访期间９例死亡，除１例原因不明外，其余由于替换瓣膜心内膜炎、血栓栓塞、心衰和瓣膜毁损所致。替换瓣膜心内膜炎、血栓栓塞、瓣膜毁掼及再手术发生率分别为：１．３２％、０．２６％、４．２２％及１．３２％病人一年。１６例瓣膜毁损中１２例为瓣叶钙化。死亡率３．６９％病人一年。５年存活率７５％。证据表明：ＹＰＶ－Ｉ型瓣膜替换二尖瓣后远期的结果是可接受的。为取得更好的效果，改进该种瓣膜是必要的。The YPV-I valve is a yak pericardial bioprosthesis with excellent hemodynamic characteristics, but the long-term effects of the valve and its durability are unknown. From May 1985 to September 1987, the valve was used for the mitral valve replacement in our hospital. After discharge, 55 patients were followed for 379. 4 patient-years(mean 6. 9 patient-years). There were 9 cases of deaths., The cause of death was unclear in one case, and other deaths were associated with prosthetic valye endocarditis(PVE), thromboembolism, heart faillure and valve deterioration. PVE rate, thromboembolism rate, valve deterioration rate and reoperative rate were 1. 32%, 0. 26 %, 4. 22%, and 1. 32 % patient-years respectively. Among 16 cases of valve deterioration, there were 12 cases of valve calcification. Mortality rate was 3. 69% patientyears. 5-year actuarial survial rate was 75 %. The available evidence indicates that long-term results of mitral valve replacement with YPV- I valve are acceptable. In order to obtain more satisfactory results, it is necessary to improve the valve.

关 键 词：生物瓣 二尖瓣 牦牛 心脏瓣膜手术 预后 

分 类 号：R654.2[医药卫生—外科学]