外源性褪黑激素对去松果体盲鼠运动性活动昼夜节律的影响  

Effect of Exogenous Melatonin on the Circadian Locomotor Rhythm in the Pineal Body's Lesion Blind Rat

作　　者：周天禄[1] 李霞[1] 钟咏梅[1] 苏兆虞[1] 

机构地区：[1]云南师范大学生命科学系

出　　处：《生物医学工程学杂志》1995年第2期142-146,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金

摘　　要：为探讨松果体褪黑激素在哺乳动物昼夜节律调控机制中的作用，本工作对外源性褪黑激素对去松果体官大鼠运动活动昼夜节律的影响进行了实验观察。经用余弦节律分析法对实验数据进行数学分析，结果发现：无论是各只动物昼夜节律振幅的算术平值，还是用群体平均余弦法得出的群体节律的振幅，用药后都大于用药前；另外，各动物节律的峰值时相用药前较分散，即个体差异较大，而用药后相对集中，比较趋于一致据此，作者认为松果体褪黑激素对哺乳动物近昼夜节律有增大振幅和内源性步化作用。To study the modulation mechanism of pineal body melatonin in mammalian circadian rhythm,we made an experiment on rats for observing the effect of exogenous melatonin on circadian locomotor rhythm in the pineal body's lesion blind rat. Cosine method was used in data analysis. The results Tevealed that the amplitude and the mean for the individual circadian rhythm or group were increased after administration of melatonin, and the acrophase dispersod among the individuals before the administration of melatonin, but it was relatively concentrated after the drug was given. Therefore, the pineal body melatonin has the effects of increasing amplitude and modulating phase on the mammalian circadian rhythms.

关 键 词：褪黑激素 昼夜节律 松果体 大鼠运动 

分 类 号：Q811.213[生物学—生物工程]