年龄对健康人红细胞与内皮细胞粘附的影响  

Effects of Aging on Adherence of Normal Erythrocyte-Vascular Endothelia

作　　者：王玲[1] 黄勋[1] 丁肇华 陈槐卿[1] 

机构地区：[1]华西医科大学生物医学工程研究室

出　　处：《生物医学工程学杂志》1995年第3期214-217,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金纽约中华医学基金

摘　　要：本文用流槽系统，定量地研究年龄对健康人红细胞与培养的人脐静脉内皮细胞粘附的影响。在本研究所选用的两个年龄阶段，其结果显示：①红细胞自身特性的改变对粘附的数目没有明显的影响，但随着年龄的增加粘附的强度增大；②在自体血浆存在时，随着年龄的增加红细胞与内皮细胞的粘附增强。这可能与心脑血管病如心肌梗塞、脑血栓形成等多发生在４０岁以上的中老年人有关。Using flow chamber system, we quantitatively studied the effects of aging on the adherence of normal erythrocytes (NRBCs) to cultured human umbilical vein endothelial cells (HUVECs). The result showed in two age stages of our research: (1)There was no significant difference of the adherence number of NRBCs to HUVECs with the increase of age, but the adhesion intensity of NRBCs to HUVECs was enhanced ; (2) The adherence of NBRCs to HUVECs was enchanced with the increase of age in autologous plasma. It may be one of the pathophysiological base that some diseases such as myocardial infarction and cerebral thrombosis often occur in adult of over 40 years.

关 键 词：年龄 红细胞 内皮细胞 粘附 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学]